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AMP Deaminase Isozymes in Human Blood Cells

  • Nobuaki Ogasawara
  • Haruko Goto
  • Yasukazu Yamada
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 165)

Abstract

AMP deaminase catalyzed the effective irreversible hydrolytic deamination of AMP to IMP and ammonia. This enzyme is widely distributed among mammalian cell types and is found in varying amounts among different tissues. Although AMP deaminase has been implicated in a number of physiological processes, its precise roles in cellular function is not clearly understood. It has been proposed that deamination of AMP is important to the purine nucleotide cycle1, and to the interconversion of adenosine, inosine and guano-sine nucleotides2. The importance of AMP deaminase in the regulation and maintenance of adenylate energy charge and adenylate pool size has also been described3.

Keywords

Purine Nucleotide Adenylate Energy Charge Human Blood Cell Mammalian Cell Type Mononuclear Cell Fraction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    J. M. Lowenstein and K. Tornheim, Ammonia production in muscle: the purine nucleotide cycle, Science 171: 397 (1971).PubMedCrossRefGoogle Scholar
  2. 2.
    B. Cunningham and J. M. Lowenstein, Regulation of adenylate deaminase by adenosine triphosphate, Biochim. Biophys. Acta 96: 535 (1965).PubMedCrossRefGoogle Scholar
  3. 3.
    A. G. Chapman and D. E. Atkinson, Stabilization of a adenylate energy charge by the adenylate deaminase reaction, J. Biol. Chem. 248: 8309 (1973).PubMedGoogle Scholar
  4. 4.
    N. Ogasawara, H. Goto, Y. Yamada, T. Watanabe and T. Asano, AMP deaminase isozymes in human tissues, Biochim. Biophys. Acta 714: 298 (1982).PubMedCrossRefGoogle Scholar
  5. 5.
    W. N. Fishbein, V. W. Armbrustmacher and J. L. Griffin, Myo-adenylate deaminase deficiency: a new disease of muscle, Science 200, 545 (1978).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Nobuaki Ogasawara
    • 1
  • Haruko Goto
    • 1
  • Yasukazu Yamada
    • 1
  1. 1.Department of Biochemistry, Institute for Developmental ResearchAichi Prefectural ColonyKasugai, AichiJapan

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