AMP Deaminase Isozymes in Human Blood Cells
AMP deaminase catalyzed the effective irreversible hydrolytic deamination of AMP to IMP and ammonia. This enzyme is widely distributed among mammalian cell types and is found in varying amounts among different tissues. Although AMP deaminase has been implicated in a number of physiological processes, its precise roles in cellular function is not clearly understood. It has been proposed that deamination of AMP is important to the purine nucleotide cycle1, and to the interconversion of adenosine, inosine and guano-sine nucleotides2. The importance of AMP deaminase in the regulation and maintenance of adenylate energy charge and adenylate pool size has also been described3.
KeywordsPurine Nucleotide Adenylate Energy Charge Human Blood Cell Mammalian Cell Type Mononuclear Cell Fraction
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