Abstract
Kainate was found to decrease the energy charge of cerebellar slices and increase inosine monophosphate levels. In addition, it caused leakage of glutamate and aspartate from the tissue and decreased the synthesis of glutamine from a variety of radioactive precursors. These effects were attributed to alterations in glial cells secondary to massive depolarization of neurons. These results and those of others are discussed in terms of their implication for the mechanism of neurotoxicity of excitatory substances.
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Nicklas, W.J. (1983). Alteration by Kainate of Energy Stores and Neuronal-Glial Metabolism of Glutamate In Vitro . In: Fuxe, K., Roberts, P., Schwarcz, R. (eds) Excitotoxins. Wenner-Gren Center International Symposium Series. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0384-9_5
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DOI: https://doi.org/10.1007/978-1-4757-0384-9_5
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