Identification of Excitatory Amino Acid Pathways in the Mammalian Nervous System

  • F. Fonnum
  • V. M. Fosse
  • C. N. Allen
Part of the Wenner-Gren Center International Symposium Series book series (WGCISS)


Although the short-lasting excitatory action of glutamate on neurons was demonstrated more than 20 years ago (Curtis and Watkins, 1960), it has proved difficult to confirm its role as a neurotransmitter in the mammalian CNS. Unlike other putative neurotransmitters, glutamate fullfills a multitude of tasks in the brain. It is involved in energy metabolism and fatty acid synthesis, incorporated into proteins and peptides and is even a precursor for the inhibitory neurotransmitter GABA. In addition its action as a neuroexcitant has been regarded as universal and non-specific.


Visual Cortex Nucleus Accumbens Superior Colliculus Kainic Acid Aspartate Transaminase 
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Copyright information

© The Wenner-Gren Center 1983

Authors and Affiliations

  • F. Fonnum
    • 1
  • V. M. Fosse
    • 1
  • C. N. Allen
    • 1
  1. 1.Division of ToxicologyNorwegian Defence Research EstablishmentKjellerNorway

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