Disorderly Drinking During Development in Spontaneously Hypertensive Rats

  • F. Scott Kraly
Part of the NATO ASI Series book series (NSSA, volume 105)


Adult spontaneously hypertensive rats (SHR) drink more water than do Wistar-Kyoto (WKY) rats when they have free access to solid food and water, and adult SHR exhibit hyperdipsia when eating a meal of solid food.1 In addition, SHR exhibit a disproportionate (relative to WKY) acute increase in mean blood pressure when drinking water.2 To examine whether hyperdipsia occurs in young SHR and whether it contributes to the development of hypertension, experiments were done (a) to describe ingestion during development of male SHR and WKY, (b) to examine for a mechanism for hyperdipsia in SHR, and (c) to evaluate whether restriction of water intake can slow or prevent the development of hypertension in SHR.


Solid Food Restricted Access Liquid Food Unlimited Access Dietary Sodium Restriction 
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  1. 1.
    F.S. Kraly, A.F. Moore, L.A. Miller, and A. Drexler, Nocturnal food-related hyperdipsia in the adult spontaneously hypertensive rat. Physiol. Behav. 28: 885 (1982).PubMedCrossRefGoogle Scholar
  2. 2.
    J.E. LeDoux, A. Sakaguchi, and D.J. Reis, Behaviorally selective cardiovascular hyperreactivity in spontaneously hypertensive rats. Hypertension 4: 853 (1982).PubMedCrossRefGoogle Scholar
  3. 3.
    F.S. Kraly, The physiology of drinking elicited by eating. Psych. Rev. 91: in press (1984).Google Scholar
  4. 4.
    N.C. Trippodo and E.D. Frohlich, Similarities of genetic (spontaneous) hypertension: Man and rat. Circ. Res. 48: 309 (1981).PubMedCrossRefGoogle Scholar
  5. 5.
    A.N. Epstein, D. Spector, A. Samman, and C. Goldblum, Exaggerated prandial drinking in the rat without salivary glands. Nature 201: 1342 (1964).PubMedCrossRefGoogle Scholar
  6. 6.
    H.R. Kissileff, Oropharyngeal control of prandial drinking. J. Comp. Physiol. Psych. 67: 309 (1969).CrossRefGoogle Scholar
  7. 7.
    E.M. Strieker, Influence of saliva on feeding behavior in the rat. J_. Comp. Physiol. Psych. 70: 103 (1970).CrossRefGoogle Scholar
  8. 8.
    G.L. Wright, J.P. McMurty, and B.C. Wexler, Food restriction reduces blood pressure of the spontaneously hypertensive rat. Life Sci. 28: 1253 (1981).PubMedCrossRefGoogle Scholar
  9. 9.
    J.B. Young, D. Mullen, and L. Landsberg, Caloric restriction lowers blood pressure in the spontaneously hypertensive rat. Metabolism 27: 1711 (1978).PubMedCrossRefGoogle Scholar
  10. 10.
    W.H. Beierwaltes, W.J. Arendshorst, and P.J. Klemmer, Electrolyte and water balance in young spontaneously hypertensive rats. Hypertension 4: 908 (1982).PubMedCrossRefGoogle Scholar
  11. 11.
    C.B. Toal and F.H.H. Leenen, Dietary sodium restriction and development of hypertension in spontaneously hypertensive rats. Am. J. Physiol. 245: H1081 (1983).PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • F. Scott Kraly
    • 1
  1. 1.Department of PsychologyColgate UniversityHamiltonUSA

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