Disorderly Drinking During Development in Spontaneously Hypertensive Rats
Part of the
NATO ASI Series
book series (NSSA, volume 105)
Adult spontaneously hypertensive rats (SHR) drink more water than do Wistar-Kyoto (WKY) rats when they have free access to solid food and water, and adult SHR exhibit hyperdipsia when eating a meal of solid food.1 In addition, SHR exhibit a disproportionate (relative to WKY) acute increase in mean blood pressure when drinking water.2 To examine whether hyperdipsia occurs in young SHR and whether it contributes to the development of hypertension, experiments were done (a) to describe ingestion during development of male SHR and WKY, (b) to examine for a mechanism for hyperdipsia in SHR, and (c) to evaluate whether restriction of water intake can slow or prevent the development of hypertension in SHR.
KeywordsSolid Food Restricted Access Liquid Food Unlimited Access Dietary Sodium Restriction
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