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Biochemical, Physiological and Pathological Properties of Endogenous Digitalis-Like Compounds

  • Jean-François Cloix
  • Gilbert Deray
  • Marie-Aude Devynck
  • Marie-Gabrielle Pernollet
  • Maryse Crabos
  • Geneviève Henning
  • Max Rieux
  • Irving W. Wainer
  • Philippe Meyer
Part of the NATO ASI Series book series (NSSA, volume 105)

Abstract

Sodium and water homeostasis are regulated by intrarenal physical and hormonal factors and by extrarenal hormones. The latter include factors retaining Na+ and water, and factors eliminating Na+ while the sodium balance is positive. There is a relationship between arterial blood pressure, Na+ homeostasis and body fluid volumes (1), and an increase in blood pressure may result from the incapacity of the kidney to eliminate a Na+ and water loading (2). This renal defect in the excretion of Na+ leads to an extracellular volume expansion which in turn, increases the activity or the concentration of a natriuretic hormone through hypothalamic stimulation (2).

Keywords

Essential Hypertension Plasma Extract Active Acromegaly Anephric Patient Body Fluid Volume 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Jean-François Cloix
    • 1
  • Gilbert Deray
    • 1
  • Marie-Aude Devynck
    • 1
  • Marie-Gabrielle Pernollet
    • 1
  • Maryse Crabos
    • 1
  • Geneviève Henning
    • 1
  • Max Rieux
    • 1
    • 2
  • Irving W. Wainer
    • 1
    • 3
  • Philippe Meyer
    • 1
  1. 1.U7 INSERM, Dept of Pharmacology, Hôpital NeckerParisFrance
  2. 2.Centre de Recherches en Endocrinologie, Hôpital CochinParisFrance
  3. 3.Division of Drug ChemistryUS Food and Drug AdministrationUSA

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