Effects of Narcotic Analgesics on Water and Food Intake in Normal Rats
S.c. morphine (0.5 to 8.0 mg/kg) in normal satiated rats induces water and food intake (1,3) beginning 1–2 hours and terminated 6 hours after injection, when given during the day (light) but not during the night (dark) period (4,5). Water and food ingestion is depressed between 6 and 24 hours after injection (3). The drinking and eating responses appear to be independent of each other. A second morphine injection 6 hours after the first induces drinking, but no eating. Bilateral nephrectomy suppresses the drinking, but not the eating response (4). With daily repetition of the injections, no tolerance develops within 17 days for the drinking and eating responses to 0.5 to 16 mg/kg of morphine (2,3).
KeywordsFood Intake Water Intake Analgesic Agent Narcotic Analgesic Morphine Injection
Unable to display preview. Download preview PDF.
- 1.R. Burckhardt, G. Peters, Morphine stimulation of food and water intake in the rat. Abstracts, 7th International Congress of Physiology, Paris, Abstr. 453, pg. 177, (1978).Google Scholar
- 2.R. Burckhardt, G. Peters, Morphine-induced drinking and eating in the rat. Abstracts, 7th International Conference on the physiology of food and fluid intake, Warsaw, (1980).Google Scholar
- 3.R. Burckhardt-Stuker, Experimentelle Anaigetika-Abhängigkeit bei der Rattle (Ph. D. thesis). Berne, Frankfurt, New York, Peter Lang (1983), Pg. 218–248.Google Scholar
- 4.K. Jawaharlal, J. Atkinson, Role of the renin-angiotensin system in morphine-induced drinking (Abstract), Experientia 38: 755 (1982).Google Scholar
- 5.G. Peters, Mécanismes de réglage de l’ingestion d’eau. J. Physiol. (Paris) 76:295 (1980).Google Scholar