Dopaminergic Modulation of Choice in Salt Preference Tests
Pharmacological blockade of dopamine receptors by some neuroleptic drugs reduces fluid consumption in rats. For example, subcutaneous injections of haloperidol reduced water intake in rats which were induced to drink by water deprivation, or by subcutaneous injections of hypertonic saline, polyethylene glycol, or isoproterenol1. Three butyrophenones, droperidol, haloperidol and spiperone, each produced dose-dependent attenuation of deprivation-induced drinking2. Intracerebroventricular administration of several neuroleptics (haloperidol, fluphenazine, cis-flupenthixol, sulpiride, pimozide, chlorpromazine), in each case, caused inhibition of angiotensin-induced drinking in male rats2. Thus, there may be some dopaminergic involvement in the control of drinking responses.
KeywordsDopamine Receptor Fluid Consumption Dopamine Receptor Antagonist Total Fluid Intake Drinking Response
Unable to display preview. Download preview PDF.
- 2.N. Rowland and D. J. Engle, Feeding and drinking interactions after acute butyrophenone administration, Pharmacol. Biochem. Behav. 7: 295 (1977).Google Scholar
- 6.K. T. Borer, Disappearance of preferences and aversions for sapid solutions in rats ingesting untasted fluids, J. comp. physiol. Psychol. 65: 213 (1968).Google Scholar
- 9.J. W. Kebabian, K. Tsuruta, T. E. Cote and G. W. Grewe, The activity of substituted benzamides in biochemical models of dopamine receptors, in: “The Benzamides: Pharmacology, Neuro-biology and Clinical Aspects”, J. Rotrosen and M. Stanley, eds., Raven Press, New York (1982).Google Scholar
- 10.P. Jenner, A. Theodorou and C. D. Marsden, Specific receptors for substituted benzamide drugs in brain, in: “The Benzamides” J. Rotrosen and M. Stanley, eds., Raven Press, New York (1982).Google Scholar
- 11.J. Hyttel, SCH 23390 — the first selective dopamine D-l antagonist Europ. J. Pharmacol. 91:153 (1983).Google Scholar
- 12.S. J. Cooper and D. B. Gilbert, Naloxone suppresses fluid consumption in tests of choice between sodium chloride solutions and water in male and female water-deprived rats, Psychopharmacology. (1985) in press.Google Scholar