Dopaminergic Modulation of Choice in Salt Preference Tests

  • Steven J. Cooper
  • David B. Gilbert
Part of the NATO ASI Series book series (NSSA, volume 105)


Pharmacological blockade of dopamine receptors by some neuroleptic drugs reduces fluid consumption in rats. For example, subcutaneous injections of haloperidol reduced water intake in rats which were induced to drink by water deprivation, or by subcutaneous injections of hypertonic saline, polyethylene glycol, or isoproterenol1. Three butyrophenones, droperidol, haloperidol and spiperone, each produced dose-dependent attenuation of deprivation-induced drinking2. Intracerebroventricular administration of several neuroleptics (haloperidol, fluphenazine, cis-flupenthixol, sulpiride, pimozide, chlorpromazine), in each case, caused inhibition of angiotensin-induced drinking in male rats2. Thus, there may be some dopaminergic involvement in the control of drinking responses.


Dopamine Receptor Fluid Consumption Dopamine Receptor Antagonist Total Fluid Intake Drinking Response 
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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Steven J. Cooper
    • 1
  • David B. Gilbert
    • 1
  1. 1.Department of PsychologyUniversity of BirminghamBirminghamUK

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