Sodium Appetite After Adrenalectomy or Deoxycorticosteronetreatment in Diabetes Insipidus (Brattleboro) Rats

  • Louise M. Fuller
Part of the NATO ASI Series book series (NSSA, volume 105)


Brattleboro (BB) rats with hereditary hypothalamic diabetes insipidus have undetectable levels of vasopressin in either the brain or plasma1,2. These animals are polyuric owing to vasopressin deficiency3 and consequently they are dehydrated4. Hypovolaemia, increased plasma renin activity5 and increased plasma osmolality6 are factors that could contribute to the characteristic polydipsia3 of the BB rat. Surprisingly, plasma aldosterone is reduced in BB rats, either as a result of decreased production7, or of increased synthesis combined with high turnover8.


Diabetes Insipidus Sodium Appetite Increase Plasma Osmolality6 Negative Sodium Balance Desoxycorticosterone Acetate 
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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Louise M. Fuller
    • 1
  1. 1.The Physiological LaboratoryCambridgeEngland

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