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The Renin-Angiotensin-Aldosterone System and Sodium Appetite in Rats

  • Melvin J. Fregly
  • Neil E. Rowland
Part of the NATO ASI Series book series (NSSA, volume 105)

Abstract

Richter (1) was the first to show that bilateral adrenalectomy induced a specific appetite for sodium chloride (NaCl) solutions in rats. This appetite was normalized by adrenal cortical transplants, implicating an hormonal factor which we now recognize as aldosterone. Accordingly, administration of graded doses of aldosterone or of desoxycorticosterone acetate (DOCA) to adrenalectomized rats produced a graded reduction in salt appetite (Figure 1, top panel). However, doses of DOCA in excess of about 1 mg/kg/day increased NaCl intake, resulting in a U-shaped dose-response relationship. In these experiments 0.15 M NaCl solution was given in simultaneous choice with distilled water, the intake of which was the mirror image of the NaCl curve (Figure 1, lower panel). High doses of aldosterone or DOCA also induce sodium appetite in intact rats (2,3).

Keywords

Nucleus Tractus Solitarius Bilateral Adrenalectomy Preference Threshold Renin Substrate Salt Taste 
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References

  1. 1.
    Richter, C.P., Increased salt appetite in adrenalectomized rats, Am. J. Physiol. 115:155 (1936).Google Scholar
  2. 2.
    Fregly, M.J. and I.W. Waters, Effect of mineralocorticoids on spontaneous sodium chloride appetite of adrenalectomized rats, Physiol. Behav. 1:65 (1966).CrossRefGoogle Scholar
  3. 3.
    Wolf, G., Effect of desoxycorticosterone on sodium appetite of intact and adrenalectomized rats, Am, J. Physiol. 208: 1281 (1965).Google Scholar
  4. 4.
    Avrith, D.B. and J.T. Fitzsimons, Increased sodium appetite in the rat induced by intracranial administration of components of the renin-angiotensin system, J. Physiol. (London) 301:349 (1980).Google Scholar
  5. 5.
    Bryant, R.W., A.N. Epstein, J.T. Fitzsimons and S.J. Fluharty, Arousal of specific and persistent sodium appetite in the rat with continuous intracerebroventricular infusion of angiotensin II, J. Physiol. (London) 301:365 (1980).Google Scholar
  6. 6.
    Beaumont, K. and D.D. Fanestil, Characterization of rat brain aldosterone receptors reveals high affinity for corticosterone, Endocrinology 113:2043 (1983).PubMedCrossRefGoogle Scholar
  7. 7.
    Fluharty, S.J. and A.N. Epstein, Sodium appetite elicited by intracerebroventricular infusion of angiotensin II in the rat II: Synergistic interaction with systemic mineralocorticoids, Behav. Neurosci. 97:746 (1983).PubMedCrossRefGoogle Scholar
  8. 8.
    Fregly, M.J., J.R. Cade, I.W. Waters, J.A. Straw and R.E. Taylor, Jr., Secretion of aldosterone by adrenal glands of propylthiouracil-treated rats, Endocrinology 77:777 (1965).PubMedCrossRefGoogle Scholar
  9. 9.
    Evered, M.D., M. M. Robinson and M.A. Richardson, Captopril given intracerebroventricularly, subcutaneously or by gavage inhibits angiotensin-converting enzyme activity in the rat brain, Europ. J. Pharmacol. 68:443 (1980).CrossRefGoogle Scholar
  10. 10.
    Fregly, M.J., N.E. Rowland and W.G. Luttge, Effect of chronic administration of desoxycorticosterone acetate (DOCA) on salt appetite of captopril-treated rats, Fed. Proc. 43:717 (1984).Google Scholar
  11. 11.
    Richter, D.P., Salt taste thresholds for normal and adrenalectomized rats, Endocrinology 24:367 (1939).CrossRefGoogle Scholar
  12. 12.
    Nachman, M., Taste preference for sodium salts by adrenalectomized rats, J. Comp. Physiol. Psychol. 55:1124 (1962).PubMedCrossRefGoogle Scholar
  13. 13.
    Fregly, M.J. and I.W. Waters, Effect of propylthiouracil on the preference thresholds of rats for NaCl solution, Proc. Soc. Exp. Biol. Med. 120:637 (1965).PubMedCrossRefGoogle Scholar
  14. 14.
    Thrasher, T.N. and M.J. Fregly, Factors affecting salivary sodium concentration, NaCl intake, and preference threshold and their interrelationship, in Biological And Behavioral Aspects Of Salt Intake, eds. M.R. Kare, M.J. Fregly and R.A. Bernard, Pergamon Press, NY, p. 145 (1980).Google Scholar
  15. 15.
    Fregly, M.J., Effect of an oral contraceptive on NaCl appetite and preference threshold in rats, Pharmac. Biochem. Behav. 1: 61 (1973).CrossRefGoogle Scholar
  16. 16.
    Fregly, M.J., Effect of hydrochlorothiazide on preference threshold of rats for NaCl solutions, Proc. Soc. Exper. Biol. Med. 125: 1079 (1967).CrossRefGoogle Scholar
  17. 17.
    Fregly, M.J., Effect of the angiotensin converting enzyme inhibitor, captopril, on NaCl appetite of rats, J. Pharm. Exp. Therap. 215:407 (1980).Google Scholar
  18. 18.
    Pfaffman, C. and J.K. Bare, Gustatory nerve discharges in normal and adrenalectomized rats, J. Comp. Physiol. Psychol. 43:320 (1950).CrossRefGoogle Scholar
  19. 19.
    Contreras, R.J., T. Kosman and M.E. Frank, Activity in salt taste fibers: peripheral mechanism for mediating changes in salt intake, Chemical Senses 8:275 (1984).CrossRefGoogle Scholar
  20. 20.
    Matuso, R., N. Shimizu and K. Kosano, Lateral hypothalamic modulation of oral sensory afferent activity in nucleus tractus solitarius neurons of rats, J. Neurosci, 4:1201 (1984).Google Scholar

Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Melvin J. Fregly
    • 1
  • Neil E. Rowland
    • 1
  1. 1.Department of Physiology and Psychology, Colleges of Medicine and Liberal Arts and SciencesUniversity of FloridaGainesvilleUSA

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