Sodium Appetite During Captopril Blockade of Endogenous Angiotensin Formation
Activation of the renin-angiotensin-aldosterone system during sodium deficiency is directly or indirectly responsible for many compensatory physiological responses which act to conserve both sodium and water1. Moreover, there is a large and increasing body of evidence for a role of angiotensin (ANG) in salt appetite, the behavioral partner to these conservation mechanisms. For example, it is well-established that administration of ANG can arouse a salt appetite in sodium-replete rats2,3. However, in natural situations, ANG probably acts in conjunction with aldosterone. Epstein and colleagues have recently shown that when the two hormones are administered together, at very low doses they act synergistically to produce the appetite4. Thus, concurrent elevation of the two hormones, as in sodium deficiency, may be an important mechanism by which the appetite is aroused.
KeywordsPeripheral Administration Sodium Depletion Depletion Period Sodium Deficiency Salt Appetite
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- 5.R.M. Elfont and J.T. Fitzsimons, The role of angiotensin in increased sodium appetite after adrenalectomy. J. Physiol. 320:70P (1981).Google Scholar