The Hormones of Renal Sodium Conservation Act Synergistically to Arouse a Sodium Appetite in the Rat

  • Randall R. Sakai
Part of the NATO ASI Series book series (NSSA, volume 105)

Abstract

Central or systemic administration of angiotensin1,2,4 as well as peripheral administration of either desoxycorticosterone acetate (DOCA) or aldosterone8,9 will arouse a sodium appetite in the rat but only when large doses of the hormone are used or when negative sodium balance is induced6,7, Recently, Epstein3 has suggested that these same hormones may act in a synergistic manner at physiological concentrations, to produce a sodium appetite and that their concurrent action may underly the sodium appetite which occurs naturally in states of sodium depletion. Fluharty and Epstein5 have since supported this hypothesis by arousing a rapid and robust sodium appetite upon central administration of angiotensin II (Ang II) to sodium replete rats given subcutaneous injections of DOCA. The doses of both hormones were insufficient to arouse a sodium appetite when given alone, and the appetite occured in animals that were in positive sodium balance. We have now extended this line of investigation to the naturally occuring mineralocorticoid, aldosterone, enquiring whether it is the synergistic partner with angiotensin II in generating the appetite.

Keywords

Cage Angiotensin Glucocorticoid Acetylcholine Aldosterone 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    D.B. Avrith & J.T. Fitzsimons, Increased sodium appetite in the rat induced by intracranial administration of components of the renin-angiotensin system. J. of Physiol. 301: 349–364 (1980).Google Scholar
  2. 2.
    R.W. Bryant, A.N. Epstein, J.T. Fitzsimons & S.J. Fluharty, Arousal of a specific and persistent sodium appetite in the rat with continuous intracerebroventricular infusion of angiotensin II. J. of Physiol. 301: 365–382 (1980).Google Scholar
  3. 3.
    A.N. Epstein, Mineralocorticoid and cerebral angiotensin may act together to produce a sodium appetite. Peptides, 103: 60–65 (1982).Google Scholar
  4. 4.
    A.R.L. Findaly & A.N. Epstein, Increased sodium intake is somehow induced in rats by intravenous angiotensin II. Hormones & Behav. 14: 86–92.Google Scholar
  5. 5.
    S.J. Fluharty & A.N. Epstein, Sodium appetite elicited by intracerebroventricular infusion of angiotensin II in the rat: II. Synergistic interaction with systemic mineralocorticoids. Behav. Neurosci. 97: 746–758 (1983).PubMedCrossRefGoogle Scholar
  6. 6.
    S.J. Fluharty & S. Manaker, Sodium appetite elicited by intracerebroventricular infusion of angiotensin II in the rat: I. Relationship to urinary sodium excretion. Behav. Neurosci. 97: 738-745.Google Scholar
  7. 7.
    M.J. Fregly & I.W. Waters, Effect of mineralocorticoids on spontaneous sodium chloride appetite of adrenalectomized rats. Physiol. & Behav. 1: 65–74 (1966).CrossRefGoogle Scholar
  8. 8.
    K.K. Rice & C.P. Richter, Increased sodium chloride and water intake of normal rats treated with desoxycorticosterone acetate. Endocrinol. 33.: 106–115 (1943).CrossRefGoogle Scholar
  9. 9.
    G. Wolf & P.J. Handal, Aldosterone-induced sodium appetite: Dose response and specificity. Endocrinol. 78: 1120–1124 (1966).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Randall R. Sakai
    • 1
  1. 1.Department of BiologyUniversity of PennsylvaniaPhiladelphiaUSA

Personalised recommendations