Influence of Sodium Load on Angiotensin-Induced Sodium Appetite
Part of the
NATO ASI Series
book series (NSSA, volume 105)
Whether or not angiotensin II (Ang II) plays a role in Na appetite is an open question1. Intracerebroventricular (I.C.V.) administration of Ang II or renin causes rats to drink hvpertonic NaCl as well as water when both solutions are available2,3,4,5. But because I.C.V. Ang II also causes natriuresis6, it has been suggested that NaCl intake is secondary to Na loss in the urine. According to Fluharty and Manaker7, I. C.V. infusion of Ang II causes a “small and brief” early phase of Na ingestion which is not the result of natriuresis, and “larger and more sustained bouts of Na ingestion” which are secondary to Na loss in the urine. On the other hand, rats given a single I.C.V injection of 50 mu renin drank sufficient hypertonic NaCl to go into positive Na balance within the first hour of injection and remain in positive balance for at least 24 h afterwards5.
KeywordsLateral Hypothalamic Area Positive Balance Sodium Load Increase Water Intake Intracerebroventricular Infusion
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