Increased Sodium Appetite and Polydipsia in Goldblatt Hypertension
Two kidney Goldblatt hypertension can be induced in the rat by complete ligation of the aorta between the renal arteries1. The ischaemic (left) kidney secretes excessive amounts of renin, resulting in plasma renin concentrations which peak during the first week after operation and return to near normal after about a month2. Occlusion of the aorta leads to polydipsia and polyuria3, with reduced preference for NaCl in the chronic stages of hypertension 4–6 weeks postoperatively4. Partial aortic occlusion, which is less lethal than complete occlusion but which produces a similar sequence of changes, was introduced in order to examine the polydipsia and changes in Na appetite that occur in renal hypertension5. The relation between blood pressure and spontaneous fluid intake was also investigated.
KeywordsRenal Artery Arterial Blood Pressure Flame Photometry Renin Secretion Aortic Occlusion
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