The Role of the Zona Incerta in Water Intake Regulation

  • Sebastian P. Grossman
Part of the NATO ASI Series book series (NSSA, volume 105)


Our understanding of the brain mechanisms that regulate water intake has undergone revolutionary change in the past decade. Where we once thought that the lateral hypothalamus controlled thirst and related behaviors, it now seems clear that we must look to the zona incerta (ZI) and preoptic region. My associates and I have intensively studied the effects of ZI lesions in the past decade. References to specific experiments and a more detailed account of our findings are available (1).


Water Intake Polyethylene Glycol Hypertonic Saline Kainic Acid Polyethylene Glycol 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    S.P. Grossman, A reassessment of the brain mechanisms that control thirst. Neurosci. Biobehav. Rev. 8:95–104 (1984).PubMedCrossRefGoogle Scholar
  2. 2.
    S.P. Grossman, D. Dacey, A.E. Halaris, T. Collier and A. Routtenberg, Aphagia and adipsia after preferential destruction of nerve cells bodies in the hypothalamus, Science 202:557–559 (1978).CrossRefGoogle Scholar
  3. 3.
    S.P. Grossman and L. Grossman, Iontophoretic injections of kainic acid into the rat lateral hypothalamus: Effects on ingestive behavior. Physiol.Behav.29:553–559 (1982).PubMedCrossRefGoogle Scholar
  4. 4.
    E.M. Stricker, A.F. Swerdloff and M.J. Zigmond, Intrahypothalamic injections of kainic acid produce feeding and drinking deficits in rats. Brain Res. 158: 470–473 (1978).PubMedCrossRefGoogle Scholar
  5. 5.
    M.D. Evered and G. J. Mogenson, Impairment in fluid ingestion in rats with lesions of the zona incerta. Am J. Physiol. 233:R53–R58 (1977).PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Sebastian P. Grossman
    • 1
  1. 1.Committee on BiopsychologyUniversity of ChicagoChicagoUSA

Personalised recommendations