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InVitro Down Regulation and Possible Internalization of Central Angiotensin Receptors

  • J. W. Harding
  • J. B. Erickson
  • J. W. Wright
  • C. G. Camara
  • R. H. Abhold
Part of the NATO ASI Series book series (NSSA, volume 105)

Abstract

Angiotensin receptors in peripheral tissues have been shown to up or down regulate in response to changes in circulating angiotensin2/3. Nevertheless it has been difficult to demonstrate changes in central angiotensin receptors in response to alterations in blood or cerebral spinal fluid (CSF) levels of angiotensins4/5. Failure to detect such changes could be the result of a dilution effect whereby only a small percentage of angiotensin receptors are exposed to altered ligand levels or a rapidly recycling population of receptors. This study demonstrates that tachyphalaxis does occur to intracerebroventricularly (ICV) applied angiotensins. This change in angiotensin sensitivity may be a result of receptor down regulation and internalization which appear to occur at least in the in vitro preparation used in this study.

Keywords

Cerebral Spinal Fluid Receptor Internalization Glomerulosa Zone Tissue Treatment Drinking Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • J. W. Harding
    • 1
  • J. B. Erickson
    • 1
  • J. W. Wright
    • 1
  • C. G. Camara
    • 1
  • R. H. Abhold
    • 1
  1. 1.Department of VCAPPWashington State UniversityPullmanUSA

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