The Organum Vasculosum Laminae Terminalis and Water Balance in Dogs

  • Terry N. Thrasher
  • David J. Ramsay
Part of the NATO ASI Series book series (NSSA, volume 105)


Circumventricular organs (CVO) are unique regions of the brain which lack the blood-brain barrier. Thus, neurons, or their processes, located within CVO’s are in relatively free communication with blood. This anatomical peculiarity and other evidence which suggests the forebrain contains osmoreceptive elements, have made the subfornical organ (SFO) and the organum vasculosum laminae terminalis (OVLT), prime candidates as receptor areas for the regulation of water balance.


Water Intake Water Balance Plasma Osmolality Circumventricular Organ Receptor Area 
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  1. 1.
    J. B. Simpson, The circumventricular organs and the central actions of angiotensin, Neuroendocrinology 33: 248 (1981).CrossRefGoogle Scholar
  2. 2.
    J. Buggy and A. K. Johnson, Preoptic-hypothalamic periventricular lesions: thirst deficits and hypernatremia, Am.J. Physiol. 233: R44 (1977).PubMedGoogle Scholar
  3. 3.
    A. K. Johnson and J. Buggy, Periventricular preoptic-hypothalamus is vital for thirst and normal water economy, Am.J. Physiol. 234: R122 (1978).PubMedGoogle Scholar
  4. 4.
    M. J. Brody and A. K. Johnson, Role of the anteroventral third ventricle region in fluid and electrolyte balance, arterial pressure regulation, and hypertension, in: “Frontiers in Neuroendocrinology”, vol. 6, L. Martini and W. F. Ganong, eds., Raven Press, New York (1980).Google Scholar
  5. 5.
    R. R. Miselis, The efferent projections of the subfornical organ of the rat: a circumventricular organ within a neural network subserving water balance, Brain Res. 230: 1 (1981).PubMedCrossRefGoogle Scholar
  6. 6.
    T. N. Thrasher, C. J. Brown, L. C. Keil, and D. J. Ramsay. Thirst and vasopressin release in the dog: an osmoreceptor or sodium receptor mechanism? Am.J. Physiol. 238: R333 (1980).PubMedGoogle Scholar
  7. 7.
    T. N. Thrasher, J. B. Simpson, and D. J. Ramsay, Lesions of the subfornical organ block angiotensin-induced drinking in the dog, Neuroendocrinology 35: 68 (1982).PubMedCrossRefGoogle Scholar
  8. 8.
    T. N. Thrasher, L. C. Keil, and D. J. Ramsay. Lesions of the organurn vasculosum of the lamina terminalis (OVLT) attenuate osmotically-induced drinking and vasopressin secretion in the dog, Endocrinology 110: 1837 (1982).PubMedCrossRefGoogle Scholar
  9. 9.
    M. J. McKinley, D. A. Denton, L. C. Leksell, D. R. Mouw, B. A. Scoggins, M. H. Smith, R. S. Weisinger, and R. D. Wright. Osmoregulatory thirst in sheep is disrupted by ablation of the anterior wall of the optic recess, Brain Res. 236: 210 (1982).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Terry N. Thrasher
    • 1
  • David J. Ramsay
    • 1
  1. 1.Department of PhysiologySchool of Medicine University of CaliforniaSan Francisco San FranciscoUSA

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