Benzodiazepine and Endorphinergic Mechanisms in Relation to Salt and Water Intake
Pharmacological treatments can be used to assess the involvement of specified neurochemical mechanisms in the control of drinking responses. The benzodiazepines are an interesting group of drugs, for which specific, high-affinity binding sites have been identified within the central nervous system1,2,3. A little more than a decade ago, Maickel and Maloney4 showed that in rats which had been adapted to a 23 h water-deprivation schedule, acute treatments with the benzodiazepine receptor agonists, diazepam or chlordiazepoxide, led to significant increases in water consumption. In addition, Falk and Burnidge5 showed that chlordiazepoxide significantly increased the level of consumption of a 1.5% NaCl solution in rehydrating rats. These studies helped to initiate an examination of the effects of drugs active at benzodiazepine receptors in relation to the controls of water and saline consumption.
KeywordsHypertonic Saline SALT Intake Endogenous Opioid Peptide Opiate Antagonist Drinking Response
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