Benzodiazepine and Endorphinergic Mechanisms in Relation to Salt and Water Intake

  • Steven J. Cooper
Part of the NATO ASI Series book series (NSSA, volume 105)


Pharmacological treatments can be used to assess the involvement of specified neurochemical mechanisms in the control of drinking responses. The benzodiazepines are an interesting group of drugs, for which specific, high-affinity binding sites have been identified within the central nervous system1,2,3. A little more than a decade ago, Maickel and Maloney4 showed that in rats which had been adapted to a 23 h water-deprivation schedule, acute treatments with the benzodiazepine receptor agonists, diazepam or chlordiazepoxide, led to significant increases in water consumption. In addition, Falk and Burnidge5 showed that chlordiazepoxide significantly increased the level of consumption of a 1.5% NaCl solution in rehydrating rats. These studies helped to initiate an examination of the effects of drugs active at benzodiazepine receptors in relation to the controls of water and saline consumption.


Hypertonic Saline SALT Intake Endogenous Opioid Peptide Opiate Antagonist Drinking Response 
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  1. 1.
    C. Braestrup and R. F. Squires, Specific benzodiazepine receptors in rat brain characterized by high-affinity 3H-diazepam binding, Proc. natn. Acad. Sci., U. S. A. 74:3805 (1977).CrossRefGoogle Scholar
  2. 2.
    H. Mohler and T. Okada, Benzodiazepine receptors: demonstration in the central nervous system, Science. 198: 849 (1977).PubMedCrossRefGoogle Scholar
  3. 3.
    W. S. Young and M. J. Kuhar, Radiohistochemical localization of benzodiazepine receptors in rat brain, J. Pharmacol. Exp. Ther. 212: 337 (1980).Google Scholar
  4. 4.
    R. P. Maickel and G. J. Maloney, Effects of various depressant drugs on deprivation-induced water consumption, Neuropharmacology. 12: 777 (1973).PubMedCrossRefGoogle Scholar
  5. 5.
    J. L. Falk and G. K. Burnidge, Fluid intake and punishmentattenuating drugs, Physiol. Behav. 5:199 (1970)PubMedCrossRefGoogle Scholar
  6. 6.
    S. J. Cooper and D. J. Sanger, Endorphinergic mechanisms in food, salt and water intake: an overview, Appetite (1984) in press.Google Scholar
  7. 7.
    D. R. Brown and S. G. Holtzman, Suppression of deprivationinduced food and water intake in rats and mice by naloxone, Pharmacol. Biochem. Behav. 11: 567 (1979).PubMedCrossRefGoogle Scholar
  8. 8.
    D. J, Sanger, Opiates and ingestive behaviour, in: “Theory in Psychopharmacology, Vol. 2”, S. J. Cooper, ed., Academic Press, London (1983).Google Scholar
  9. 9.
    S. J. Cooper, Minireview. Benzodiazepine-opiate antagonist interactions in relation to feeding and drinking behavior, Life Sci. 32: 1043 (1983).PubMedCrossRefGoogle Scholar
  10. 10.
    S. J. Cooper, Benzodiazepines, barbiturates and drinking, in: “Theory in Psychopharmacology, Vol. 2”, S. J. Cooper, ed., Academic Press, London (1983).Google Scholar
  11. 11.
    J. D. Leander, Effects of punishment-attenuating drugs on deprivation-induced drinking: implications for conflict procedures, Drug Dev. Res. 3: 185 (1983).CrossRefGoogle Scholar
  12. 12.
    S. J. Cooper, Specific benzodiazepine antagonist Ro15-1788 and thirst-induced drinking in the rat, Neuropharmacology. 21: 775 (1982).PubMedCrossRefGoogle Scholar
  13. 13.
    S. J. Cooper, Effects of chlordiazepoxide on drinking compared in rats challenged with hypertonic saline, isoproterenol or polyethylene glycol, Life Sci. 32: 2453 (1983).PubMedCrossRefGoogle Scholar
  14. 14.
    C. A. Boast, P. S. Bernard, B. S. Barbaz, and K. M. Bergen, The neuropharmacology of various diazepam antagonists, Neuropharmacology. 22:1511 (1983)PubMedCrossRefGoogle Scholar
  15. 15.
    S. J. Cooper and L. B. Estall, Behavioral pharmacology of food, water and salt intake in relation to drug actions at benzodiazepine receptors, Neurosci. Biobehav. Rev. (1985) in press.Google Scholar
  16. 16.
    C. Braestrup, M. Nielsen, T. Honore, L. H. Jensen, and E. N. Petersen, Benzodiazepine receptor ligands with positive and negative efficacy, Neuropharmacology. 22: 1451 (1983).PubMedCrossRefGoogle Scholar
  17. 17.
    M. Tang, C. Brown, D. Maier, and J. L. Falk, Diazepam-induced NaCl solution intake: independence from renal factors, Pharmacol. Biochem. Behav. 18: 983 (1983).PubMedCrossRefGoogle Scholar
  18. 18.
    M. Tang, S. Soroka, and J. L. Falk, Agonistic action of a benzodiazepine antagonist: effects of Rol5-1788 and midazolam on hypertonic NaCl intake, Pharmacol. Biochem. Behav. 18: 953 (1983).PubMedCrossRefGoogle Scholar
  19. 19.
    S. Turkish and S. J. Cooper, Enhancement of saline consumption by chlordiazepoxide in thirsty rats: antagonism by Rol5-1788, Pharmacol. Biochem. Behav. (1984) in press.Google Scholar
  20. 20.
    J. L. Falk and M. Tang, Chlordiazepoxide elevates the NaCl solution acceptance-rejection function, Pharmacol. Biochem. Behav. (1984) in press.Google Scholar
  21. 21.
    J. L. Falk and M. Tang, Midazolam-induced increases in NaCl solution ingestion: differencial effect of the benzodiazepine antagonists Rol5-1788 and CGS 8216, Pharmacol. Biochem. Behav. (1984) in press.Google Scholar
  22. 22.
    J. D. Leander and M. D. Hynes, Opioid antagonists and drinking: evidence of kappa receptor involvement, Europ. J. Pharmacol. 87: 481 (1983).CrossRefGoogle Scholar
  23. 23.
    S. J. Cooper and S. G. Holtzman, Patterns of drinking in the rat following the administration of opiate antagonists, Pharmacol. Biochem. Behav. 19: 505 (1983).PubMedCrossRefGoogle Scholar
  24. 24.
    D. R. Brown and S. G. Holtzman, Opiate antagonists: central sites of action in suppressing water intake of the rat, Brain Res. 221: 432 (1981).PubMedCrossRefGoogle Scholar
  25. 25.
    D. A. Czech, E. A. Stein, and M. J. Blake, Naloxone-induced hypodipsia: a CNS mapping study. Life Sci. 33: 797 (1983).PubMedCrossRefGoogle Scholar
  26. 26.
    S. Turkish and S. J. Cooper, Effects of a kappa receptor agonist, ethylketocyclazocine, on water consumption in water-deprived and nondeprived rats in diurnal and nocturnal tests, Pharmacol. Biochem. Behav. (1984) in press.Google Scholar
  27. 27.
    G. de Caro, L. G. Micossi, and F. Venturi, Drinking behaviour induced by intracerebroventricular administration of enkephalins to rats, Nature. 277: 51 (1979).PubMedCrossRefGoogle Scholar
  28. 28.
    F. Cantalamessa, G. de Caro, M. Massi, and L. G. Micossi, Stimulation of drinking behaviour and of renin release induced by intracerebroventricular injections of D-Ala2, D-Leu5-enkephalin to rats, Pharmacol. Res. Commun. 14: 141 (1982).PubMedCrossRefGoogle Scholar
  29. 29.
    C. G. Kuta, H. U. Bryant, J. E. Zabik, and G. K. W. Yim, Stress, endogenous opioids and salt intake, Appetite (1984) in press.Google Scholar
  30. 30.
    S. J. Cooper and S. Turkish, Effects of naloxone and its quaternary analogue on fluid consumption in water-deprived rats, Neuropharmacology. 22: 797 (1983).PubMedCrossRefGoogle Scholar
  31. 31.
    S. J. Cooper and D. B. Gilbert, Naloxone suppresses fluid consumption in tests of choice between sodium chloride solutions and water in male and female water-deprived rats, Psychopharmacology (1985) in press.Google Scholar
  32. 32.
    Y. Watanabe, T. Shibuya, B. Salafsky, and H. F. Hill, Prenatal and postnatal exposure to diazepam: effects on opioid receptor binding in rat brain cortex, Europ. J_. Pharmacol. 96: 141 (1983).CrossRefGoogle Scholar
  33. 33.
    T. Duka, M. Wüster, and A. Herz, Benzodiazepines modulate striatal enkephalin levels via gabanergic mechanism, Life Sci. 26: 771 (1980).PubMedCrossRefGoogle Scholar
  34. 34.
    S. J. Cooper, Effects of opiate antagonists and of morphine on chlordiazepoxide-induced hyperdipsia in the water-deprived rat, Neuropharmacology. 21: 1013 (1982).PubMedCrossRefGoogle Scholar
  35. 35.
    S. J. Cooper, Enhancement of osmotic-and hypovolemic-induced drinking by chlordiazepoxide in rats is blocked by naltrexone, Pharmacol. Biochem. Behav. 17: 921 (1982).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Steven J. Cooper
    • 1
  1. 1.Department of PsychologyUniversity of BirminghamBirminghamUK

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