Suppression of Water Intake by the E Prostaglandins

  • Nancy J. Kenney
Part of the NATO ASI Series book series (NSSA, volume 105)


The prostaglandins (PGs) are unsaturated fatty acids produced and released by virtually every organ of the body including the brain, the kidney and the vasculature. Since their discovery in the 1930s and synthesis in the 1960s, the list of PGs and PG-like substances, as well as the physiological systems known to be affected by these substances, has grown to immense proportions.


Water Intake Hypertonic Saline Cellular Dehydration Total Water Intake Drinking Bout 
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  1. 1.
    N. J. Kenney and A. N. Epstein, Antidipsogenic role of the E-prostaglandins, J. comp. physiol. Psychol. 92;383 (1978).CrossRefGoogle Scholar
  2. 2.
    M. F. Perez Guaita and E. Chiaraviglio, Effect of prostaglandin E1 and its biosynthesis inhibitor indomethacin on drinking in the rat, Pharmac. Biochem. Behav. 13: 787 (1980).CrossRefGoogle Scholar
  3. 3.
    S. Nicolaidis and J. T. Fitzsimons, La dépendance de la prise d’eau induite par l’angiotensine II envers la fonction vasomotrice cérébrale locale chez le rat, C. r. hebd. Seanc. Acad. Sci., Paris, Serie D, 281: 1417 (1975).Google Scholar
  4. 4.
    S. J. Fluharty, Cerebral prostaglandin biosynthesis and angiotensin-induced drinking in rats, J. comp. physiol. Psychol. 95: 915 (1981).Google Scholar
  5. 5.
    N. J. Kenney, A case study of the neuroendocrine control of goal-directed behavior: The interaction between angiotensin II and prostaglandin E1 in the control of water intake, in: “Neural Mechanisms of Goal-Directed Behavior and Learning,” R. F. Thompson, L. H. Hicks and V. B. Shvyrkov, eds., Academic Press, New York (1980).Google Scholar
  6. 6.
    W. Felberg, Body temperature and fever: Changes in our views over the last decade, Proc. R. Soc., Series B 191: 199 (1975).CrossRefGoogle Scholar
  7. 7.
    N. J. Kenney and E. Perara, Pressor action of centrally administered prostaglandin E1, Adv. Prostaglandin Thromboxane Res. 8:1225 (1980).PubMedGoogle Scholar
  8. 8.
    W. E. Hoffman and P. G. Schmid, Cardiovascular and antidiuretic effects of central prostaglandin E2, J. Physiol. 288: 159 (1979).PubMedGoogle Scholar
  9. 9.
    K. M. Skoog and N. J. Kenney, Pressor responses to central angiotensin II, prostaglandin E1 and prostaglandin E: Effects of ovarian steroids, Neuroendo. 36: 144 (1983).CrossRefGoogle Scholar
  10. 10.
    K. M. Skoog and N. J. Kenney, Influences of ovarian steroids on angiotensin-induced dipsogenesis and prostaglandin E1-induced antidipsogenesis and thermogenesis, Soc. Neurosci. Absts. 7: 639 (1981).Google Scholar
  11. 11.
    N. J. Kenney, K. E. Moe and K. M. Skoog, The antidipsogenic action of peripheral prostaglandin E2, Pharmac. Biochem. Behav. 15: 263 (1981).CrossRefGoogle Scholar
  12. 12.
    D. J. Goldstein, D. J. Marante Perez, J. P. Gunst and J. A Halperin, Prostaglandin E1 inhibits acute cell dehydration thirst, Pharmac. Biochem. Behav. 10: 895 (1979).CrossRefGoogle Scholar
  13. 13.
    M. I. Phillips and W. E. Hoffman, Sensitive sites in the brain for the blood pressure and drinking responses to angiotensin II, in: “Central Actions of Angiotensin and Related Hormones,” J. P. Buckley and C. Ferrario, eds., Pergamon, New York (1977).Google Scholar
  14. 14.
    N. J. Kenney and K. E. Moe, The role of endogenous prostaglandin E in angiotensin-II-induced drinking in rats, J. comp. physiol. Psychol. 95: 383 (1981).PubMedCrossRefGoogle Scholar
  15. 15.
    J. A. Splawinski, K. Reichenberg, J. Vetulani, J. Marchaj and J. Kaluza, Hyperthermic effect of intraventricular injections of arachidonic acid and prostaglandin E2 in the rat, Pol. J. Pharmacol. Pharm. 26: 101 (1974).PubMedCrossRefGoogle Scholar
  16. 16.
    C. Malet, H. Scherrer, J. M. Saavedra and F. Dray, Specific binding of [3H]prostaglandin E2 to rat brain membranes and synaptosomes, Brain Res. 236: 227 (1982).PubMedCrossRefGoogle Scholar
  17. 17.
    S. A. Metz, M. G. Rice and R. P. Robertson, Applications and limitations of measurement of 15-keto-13, 14-dihydro prostaglandin E2 in human blood by radioimmunoassay, Prostaglandins 17: 839 (1979).PubMedGoogle Scholar
  18. 18.
    J. C. Romero, C. L. Dunlap and C. G. Strong, The effect of indomethacin and other anti-inflamatory drugs on the reninangiotensin system, J. clin. Invest. 58: 282 (1976).PubMedCrossRefGoogle Scholar
  19. 19.
    N. J. Kenney and K. E. Moe, Cellular dehydration and hypovolemia: Effect of acetylsalicylic acid on drinking, Pharmac. Biochem. Behav. 17: 73 (1982).CrossRefGoogle Scholar
  20. 20.
    G. Feuerstein, M. Krausz and Y. Gutman, Effect of indomethacin on water intake of the rat, Pharmac. Biochem. Behav. 9: 893 (1978).CrossRefGoogle Scholar
  21. 21.
    P. C. Weber and W. Siess, Interactions of renal prostaglandins with the renin-angiotensin system, Pharmac. Ther. 15:321 (1982).CrossRefGoogle Scholar
  22. 22.
    S. L. Swartz, G. H. Williams, N. K. Hollenberg, L. Levine, R. G. Dluhy and T. J. Moore, Captopril-induced changes in prostaglandin production: Relationship to vascular response in normal men, J. Clin. Invest. 65: 1257 (1980).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Nancy J. Kenney
    • 1
  1. 1.University of WashingtonSeattleUSA

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