Angiotensin Dependent Thirst Following Polyethyleneglycol Treatment in the Rat

  • Johannes F. E. Mann
  • Siegfried Eisele
  • Detlev Ganten
  • A. Kim Johnson
  • Rainer Rettig
  • Eberhard Ritz
  • Thomas Unger
Part of the NATO ASI Series book series (NSSA, volume 105)

Abstract

We have observed that angiotensin II plasma concentrations in polyethyleneglycol (PEG) treated rats were closely correlated with water intake by the animals (1). The angiotensin II plasma levels were in the range previously determined to be dipsogenic (2). The aim of the present investigation was to establish whether the correlation between angiotensin II plasma levels and the amount of water intake in PEG treated rats was based on a causal relationship. As an investigative tool we used captopril — an angiotensin I converting enzyme inhibitor — in order to block the formation of angiotensin II from angiotensin I. We approached the problem by this pharmacological means because it was shown in isopro-terenol induced thirst that captopril may blunt water intake (3).

Keywords

Catheter Angiotensin Renin Vasopressin Captopril 

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References

  1. 1).
    A.K. Johnson, J.F.E. Mann, W. Rascher, J. Johnson, and D. Ganten, Plasma angiotensin II concentrations and experimentally induced thirst. Am. J. Physiol., 240: R229–R234, 1981.PubMedGoogle Scholar
  2. 2).
    J.F.E. Mann, A.K. Johnson, and D. Ganten, Plasma angiotensin II: dipsogenic levels and the angiotensin generating capacity of renin. Am. J. Physiol., 238: R372–R377, 1980.PubMedGoogle Scholar
  3. 3).
    M.D. Evered, and M.M. Robinson, The renin-angio-tensin system in drinking and cardiovascular responses to isoprenaline in the rat, J. Physiol., 316: 357–367, 1981.PubMedGoogle Scholar
  4. 4).
    J.F.E. Mann, W. Rascher, R. Dietz, A. Schömig, and D. Ganten, Effects of an orally active converting enzyme inhibitor, SQ 14225, on pressor responses to angiotensin administered into the brain ventricles of spontaneously hypertensive rats, Clin. Sci., 56: 585–591, 1979.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Johannes F. E. Mann
    • 1
  • Siegfried Eisele
    • 1
  • Detlev Ganten
    • 1
  • A. Kim Johnson
    • 1
  • Rainer Rettig
    • 1
  • Eberhard Ritz
    • 1
  • Thomas Unger
    • 1
  1. 1.Department of Medicine and PharmacologyUniversity of HeidelbergGermany

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