Comparison of Angiotensin II And III Induced Dipsogenicity and Pressor Action
Angiotensin III (AIII) may play a greater role in body water balance and blood pressure control than previously envisioned. AIII is the predominant circulating peptide of the rat renin-angiotensin system,1 and promotes greater neural activity than angiotensin II (AII) when microiontophoretically delivered into the subfornical organ2. Intracranial injections of AII at doses of 50 pM and above induce greater drinking and pressor action than AIII in the rat,3,4 however, doses of AII and AIII below 25 pM induce equivalent dipsogenicity5. The present investigation further compared the magnitude of dipsogenic and pressor responses elicited by intracarotid and intracerebroventricular (icv) injections of AII and AIII.
KeywordsWater Consumption Pressor Response Mean Arterial Blood Pressure Pressor Action Subfornical Organ
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