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Renin Dependence of Insulin-Induced Thirst

  • M. Costales
  • M. Vijande
  • B. Marín
  • J. I. Brime
  • P. Lopez-Sela
Part of the NATO ASI Series book series (NSSA, volume 105)

Abstract

The influence of insulin on food intake has been amply studied. However there has been little work on the effect of this hormone in water intake. In 1964 Novin1 reported increased water intake due to insulin administration, separated from its effect on food intake. Booth and Brookover2 (1968), Spitz3 (1974) and Waldbillig and Bartness4 (1981) also found similar results of stimulation of thirst by insulin. Unpublished results by Fitzsimons reveal that i.p. insulin-induced drinking (IID) is abolished by nephrectomy. It could favour the possible participation of the renin-angiotensin system in this phenomenon. Waldbillig and Bartness4 found that i.p. insulin produced neither hypovolemia non plasmatic hyperosmolality, both conditions typified as thirst stimuli. On the contrary, animals presented hypervolemia and hypoosmolality.

Keywords

Water Intake Saline Injection Increase Water Intake Central Receptor Lateral Cerebral Ventricule 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    D. Novin, The effects of insulin on water intake in the rat, in “Thirst”-Proceedings of the 1st International Symposium on Thirst in the Regulation of Body Water, ed., Pergamon Press New York (1964).Google Scholar
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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • M. Costales
    • 1
  • M. Vijande
    • 1
  • B. Marín
    • 1
  • J. I. Brime
    • 1
  • P. Lopez-Sela
    • 1
  1. 1.Department of Physiology (Medicine and Biology)University of OviedoSpain

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