Renin Dependence of Insulin-Induced Thirst
The influence of insulin on food intake has been amply studied. However there has been little work on the effect of this hormone in water intake. In 1964 Novin1 reported increased water intake due to insulin administration, separated from its effect on food intake. Booth and Brookover2 (1968), Spitz3 (1974) and Waldbillig and Bartness4 (1981) also found similar results of stimulation of thirst by insulin. Unpublished results by Fitzsimons reveal that i.p. insulin-induced drinking (IID) is abolished by nephrectomy. It could favour the possible participation of the renin-angiotensin system in this phenomenon. Waldbillig and Bartness4 found that i.p. insulin produced neither hypovolemia non plasmatic hyperosmolality, both conditions typified as thirst stimuli. On the contrary, animals presented hypervolemia and hypoosmolality.
KeywordsWater Intake Saline Injection Increase Water Intake Central Receptor Lateral Cerebral Ventricule
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