The Role of the Renal Renin-Angiotensin System in Thirst

  • Alan Kim Johnson
  • Marilyn M. Robinson
  • Johannes F. E. Mann
Part of the NATO ASI Series book series (NSSA, volume 105)


Drinking is a homeostatic behavior that can correct body fluid deficits. Water deprivation produces dehydration of both the cellular and extracellular fluid compartments of the body. Cellular dehydration is caused by osmosis whenever the osmolality of the extracellular fluid is increased by solutes to which the cell membrane is not freely permeable. It is well established that this cellular dehydration is a potent stimulus to thirst and antidiuresis1. Likewise, Fitzsimons2 and others3,4 have shown that isotonic depletion of the extracellular fluid compartment by the subcutaneous or intraperitoneal injection of a hypertonic colloid solution such as polyethylene glycol (PEG) also causes drinking.


Plasma Renin Activity Water Deprivation Extracellular Fluid Volume Cellular Dehydration Drinking Response 
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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Alan Kim Johnson
    • 1
  • Marilyn M. Robinson
    • 2
  • Johannes F. E. Mann
    • 3
  1. 1.Departments of Psychology and Pharmacology and the Cardiovascular CenterUniversity of IowaIowa CityUSA
  2. 2.Department of PhysiologyUniversity of Western OntarioLondonCanada
  3. 3.Department of MedicineUniversity of HeidelbergGermany

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