Decreased Binding Capacity of Central Angiotensin II Receptors Following Long-Term Administration of Angiotensin II
A substantial body of evidence supports the existence of a brain renin-angiotensin system in the rat. All the components of the renin-angiotensin system have been demonstrated in the brain.1 Although a primary physiological role for the brain renin-angiotensin system (BRS) has not been clearly defined, the evidence strongly suggests that it plays a part in controlling water balance in the rat. So, it has been suggested that a dysfunctioning BRS could contribute to hypertension.2 Therefore, an understanding of all aspects of the BRS is important. The aspect considered here was the regulation of central Ang II receptors after chronic infusion of Ang II into the brain. As chronic infusion of Ang II into the lateral ventricles alters water intake,3 salt intake,4 natriuresis,5 and blood pressure when given in high enough doses or in combination with a high sodium diet.6,7
KeywordsSubfornical Organ Chronic Infusion High Sodium Diet Intracerebroventricular Infusion Ethylenediaminetetracetic Acid
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