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Aspects of Cerebrospinal Fluid Pressure Control in Conscious Rats During Central Infusions of Angiotensin and Vasopressin

  • W. B. Severs
  • H. J. Spaeth
  • J. N. D. Wurpel
  • R. L. Dundore
  • R. T. Henry
  • L. C. Keil
Part of the NATO ASI Series book series (NSSA, volume 105)

Abstract

The cerebrospinal fluid (CSF) system has been described as a moderately distensible compartment, wherein pressure is maintained within relatively narrow limits.1 The principal components regulating CSF dynamics are synthesis rate, compliance, and drainage (mainly at arachnoid villa). Angiotensin2 and vasopressin3 have been associated with choroid tissue, although a role for the peptides has not emerged; both peptides are endogenous to CSF.4 Vasopressin, in anesthetized rabbits, reduced CSF pressure most likely by facilitating CSF transport to venous blood.5 This peptide may also alter intracranial water movement.6 Angiotensin has been reported to cause cerebral vasoconstriction by a central mechanism.7 Thus, the peptides may affect intracranial pressure.

Keywords

Arginine Vasopressin Guide Cannula Cerebral Vasoconstriction Angiotensin Receptor Antagonist Cerebrospinal Fluid Pressure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • W. B. Severs
    • 1
    • 2
  • H. J. Spaeth
    • 1
    • 2
  • J. N. D. Wurpel
    • 1
    • 2
  • R. L. Dundore
    • 1
    • 2
  • R. T. Henry
    • 1
    • 2
  • L. C. Keil
    • 1
    • 2
  1. 1.Pharmacology DepartmentThe Milton S. Hershey Medical Ctr. of the Pennsylvania State Univ.HersheyUSA
  2. 2.NASA, Ames Res. Ctr.Moffett FieldUSA

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