Hyperosmotic Thirst: An Osmoreceptor Mechanism, a Sodium Receptor Mechanism or Both

  • Simon N. Thornton
Part of the NATO ASI Series book series (NSSA, volume 105)


Thirst has been divided into two categories, the first, primary, that which is involved in the regulation of body fluid homeostasis and the second that which is not involved in direct regulation of body fluids. Primary thirst has been further divided into having an extracellular origin and an intracellular origin. Extracellular thirst is involved during decreases in blood volume, resulting for example from haemorrhage, and appears to be mediated in part by angiotensin II (AII). Intracellular thirst is initiated by an increase in the ‘effective’ osmotic pressure of the blood i.e. when there is an increase in the concentration of solutes that do not readily penetrate cell membranes.


Hypertonic Solution Penetrate Cell Membrane Osmotic Load Osmotic Stimulus Body Fluid Homeostasis 
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  1. 1.
    E. B. Verney, The antidiuretic hormone and the factors which determine its release, Proc. R. Soc. B 135: 25 (1950).CrossRefGoogle Scholar
  2. 2.
    A. V. Wolf, Osmometric analysis of thirst in man and dog. Amer. J. Physiol. 161: 75 (1950).PubMedGoogle Scholar
  3. 3.
    B. Andersson, Regulation of water intake, Physiological reviews 58: 582 (1978).PubMedGoogle Scholar
  4. 4.
    K. Olsson, Attenuation of dehydrative thirst by lowering the C.S.F. (Na+), Acta Physiol. Scand. 94: 536 (1975).PubMedCrossRefGoogle Scholar
  5. 5.
    T. N. Thrasher, C. J. Brown, L. C. Keil and D. J. Ramsay, Thirst and vasopressin release in the dog: an osmoreceptor or sodium receptor mechanism, Amer. J. Physiol. 238:R333 (1980).PubMedGoogle Scholar
  6. 6.
    M. J. McKinley, D. A. Denton and R. S. Weisinger, Sensors for antidiuresis and thirst: osmoreceptors or C.S.F. sodium detectors, Brain Res. 141: 89 (1978).PubMedCrossRefGoogle Scholar
  7. 7.
    S. N. Thornton, Drinking and renal responses to peripherally administered osmotic stimuli in the pigeon (Columba livia), J. Physiol. 351: 501 (1984).PubMedGoogle Scholar
  8. 8.
    J. T. Fitzsimons, M. Massi and S. N. Thornton, Permissive effect of cerebrospinal fluid [Na] or drinking in response to cellular dehydration in the pigeon Columba livia, J. Physiol. 315:14 (1981).Google Scholar
  9. 9.
    J. T. Fitzsimons, The effects of slow infusions of hypertonic solutions on drinking and drinking thresholds in rats. J. Physiol. 167: 344 (1963).PubMedGoogle Scholar
  10. 10.
    E. M. Blass and W. G. Hall, Behavioural and physiological bases of drinking in water deprived rats, Nature (Lond). 249: 485 (1974).CrossRefGoogle Scholar
  11. 11.
    Unpublished results.Google Scholar

Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Simon N. Thornton
    • 1
  1. 1.Institute of Animal Physiology BabrahamCambridgeEngland

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