Abstract
We have previously reported that administration of vasopressin (AVP) to the third ventricle (3rdV) stimulates intake of water in normally hydrated dogs1. It has been also found that concentration of AVP in the cerebrospinal fluid (CSF) changes in parallel to body fluid osmolality2,3. The present study was aimed at elucidating whether centrally released endogenous AVP may be of physiological significance for the control of the osmotic thirst. To this end the osmotic thirst threshold and the postthreshold intake of water as well as restitution of plasma osmolality were determined under control conditions and after administration of competitive antagonists of AVP.
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Szczepańska-Sadowska, E., Sobocińska, J., Kozłowski, S. (1986). Osmotic Thirst Suppression after Central Administration of Vasopressin Antagonists. In: de Caro, G., Epstein, A.N., Massi, M. (eds) The Physiology of Thirst and Sodium Appetite. NATO ASI Series, vol 105. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0366-5_14
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DOI: https://doi.org/10.1007/978-1-4757-0366-5_14
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