Osmotic Thirst Suppression after Central Administration of Vasopressin Antagonists
We have previously reported that administration of vasopressin (AVP) to the third ventricle (3rdV) stimulates intake of water in normally hydrated dogs1. It has been also found that concentration of AVP in the cerebrospinal fluid (CSF) changes in parallel to body fluid osmolality2,3. The present study was aimed at elucidating whether centrally released endogenous AVP may be of physiological significance for the control of the osmotic thirst. To this end the osmotic thirst threshold and the postthreshold intake of water as well as restitution of plasma osmolality were determined under control conditions and after administration of competitive antagonists of AVP.
KeywordsPlasma Osmolality Competitive Antagonist Guide Tube Osmotic Load Intraventricular Infusion
Unable to display preview. Download preview PDF.
- 6.M. Kruszynski, B. Lammek, M. Manning, J. Seto, J. Haldar, and W.H. Sawyer. 1-(β-Mercapto-β,β-cyclopentamethylenepropionic acid), 2-(-O-methyl-thyrosine-arginine-vasopressin and 1-(β-Mercapto-β,β-cyclopentamethylenepro-pionic acid)arginine vasopressin, two highly potent antagonists of the vasopressor response to arginine-vasopressin, J. Med. Chem. 23:364 (1980).PubMedCrossRefGoogle Scholar
- 8.M. Manning and W.H. Sawyer, Design of potent and selective in vivo antagonists of the neurohypophysial peptides. In: The Neurohypophysis: Structure, Function and Control, Progress in Brain Research, vol. 60, B.A. Cross and G. Leng ed., Elsevier, Amsterdam-New York (1983) p. 367.CrossRefGoogle Scholar
- 9.J.P. Liard, O. Deriaz, P. Schelling, and M. Thibonnier, Cardiac output distribution during vasopressin infusion or dehydration in conscious dogs. Am. J. Physiol. 243:663 (1982).Google Scholar
- 10.F.L. Stassen, W. Bryan, M. Gross, B. Karanagh, D. Shue, L. Sulat, V.D. Wiebelhaus, N. Yim, and L.B. Kinter, Critical differences between species in the in vivo and in vitro renal responses to antidiuretic hormone antagonists. In: The Neurohypophysis: Structure, Function and Control. Progress in Brain Research, vol. 60. B.A. Cross and G. Leng, ed., Elsevier, Amsterdam-New York (1983) p. 395.CrossRefGoogle Scholar