Osmotic Thirst Suppression after Central Administration of Vasopressin Antagonists

  • Ewa Szczepańska-Sadowska
  • Jadwiga Sobocińska
  • Stanisław Kozłowski
Part of the NATO ASI Series book series (NSSA, volume 105)


We have previously reported that administration of vasopressin (AVP) to the third ventricle (3rdV) stimulates intake of water in normally hydrated dogs1. It has been also found that concentration of AVP in the cerebrospinal fluid (CSF) changes in parallel to body fluid osmolality2,3. The present study was aimed at elucidating whether centrally released endogenous AVP may be of physiological significance for the control of the osmotic thirst. To this end the osmotic thirst threshold and the postthreshold intake of water as well as restitution of plasma osmolality were determined under control conditions and after administration of competitive antagonists of AVP.


Plasma Osmolality Competitive Antagonist Guide Tube Osmotic Load Intraventricular Infusion 
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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Ewa Szczepańska-Sadowska
    • 1
  • Jadwiga Sobocińska
    • 1
  • Stanisław Kozłowski
    • 1
  1. 1.Microcirculation Research Unit and Department of Applied PhysiologyInstitute of Physiological Sciences, School of MedicineWarsawPoland

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