Hyperosmotic and Hypovolemic Thirst

  • David J. Ramsay
  • Terry N. Thrasher
Part of the NATO ASI Series book series (NSSA, volume 105)


The volume and composition of the extracellular fluid is controlled within very narrow limits in terrestrial mammals. This process depends upon the ability of the animal to vary urinary volume and concentration over a wide range and on the ability to regulate water intake homeostatically.1 Additionally, it is becoming clear that sodium excretion and possibly sodium intake may also be regulated in order to maintain a constancy of plasma osmolality.2 For example, if a dog is deprived of water for 24 hours while allowed access to food, its plasma osmolality increases by approximately 10 mosmol/Kg. This is accomplished by renal conservation of water together with a marked natriuresis. Dogs will rapidly make up their water deficits when allowed access to water.3 The major emphasis in this review will be the mechanisms which regulate water intake.


Water Intake Plasma Osmolality Renin Angiotensin System Vasopressin Secretion Extracellular Fluid Volume 
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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • David J. Ramsay
    • 1
  • Terry N. Thrasher
    • 1
  1. 1.Department of PhysiologyUniversity of CaliforniaSan Francisco San FranciscoUSA

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