Heart Rate Variability in Autonomic Neuropaths and Newborn Babies

  • R. I. Kitney
Part of the NATO ASI Series book series (NSSA, volume 114)


This Chapter will discuss two areas where the application of HRV analysis is likely to be of clinical significance. First the application to HRV is neuropaths and second to HRV in the newborn. In both case the discussion will draw on the information presented in the previous Chapter which relates to normal adult HRV.


Heart Rate Variability Sudden Infant Death Syndrome Autonomic Neuropathy Respiratory Sinus Arrhythmia Power Spectral Density Function 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Van der Akker, T. J., Koelman, A. S. M., Hogenhuis, L. A. H., and Rompelman, O., 1983, Heart rate variability and blood pressure oscillations in diabetics with autonomic neuropathy, Automedica, 4:201–208.Google Scholar
  2. Angelone, A., and Coulter, N. A., 1964, Respiratory sinus arrhythmia: a frequency dependent phenomenon, J. Appl. Physiol., 19:479–482.PubMedGoogle Scholar
  3. Giddens, D. P., and Kitney, R. I., in press, Neonatal heart rate variability and its relation to respiration, J. Theoret. Biol.Google Scholar
  4. Hathorn, M. K. S., 1974, Rate and depth breathing in newborn infants, in different sleep stages, J. Physiol., 243:101–113.PubMedGoogle Scholar
  5. Hathorn, M. K. S., 1977, Analysis of the rhythm of infantile breathing, Br. Med. Bull., 31:8–12.Google Scholar
  6. Hirsch, J. A., and Bishop, B., 1981, Respiratory sinus arrhythmia in humans: how breathing pattern modulates heart rate, Am. J. Physiol., 241: H620–629.PubMedGoogle Scholar
  7. Holmes, A. K., 1982, A study of heart rate variability in neonates during sleep, MSc. Thesis, London University.Google Scholar
  8. Hyndman, B. W., 1974, The role of rhythms in homeostasis, Kybernetik, 15:227–236.PubMedGoogle Scholar
  9. Hyndman, B. W., 1980, Cardiovascular recovery to psychological stress: a means to diagnose man and task?, in: “The Study of Heart Rate Variability” , R. I. Kitney and O. Rompelman, eds., Clarendon Press, Oxford.Google Scholar
  10. Kitney, R. I., 1972, The thermo-regulatory control system in man and its study by digital computer simulation, PhD Thesis, London University.Google Scholar
  11. Kitney, R. I., 1974, The analysis and simulation of the human thermoregulator control system, Medical & Biological Engineering, Jan. 57–65.Google Scholar
  12. Kitney, R. I., 1979, A nonlinear model for studying oscillations in the blood pressure control system, J. Biomedical Engineering, 1:89–99.CrossRefGoogle Scholar
  13. Kitney, R. I., 1980, An analysis of the thermoregulatory influences on heart rate variability, in: “The Study of Heart Rate Variability”, R. I. Kitney and O. Rompelman, eds., Clarendon Press, Oxford.Google Scholar
  14. Kitney, R. I., 1981, Modelling respiratory sinus arrhythmia and its application to the study of neuropathy, in: “Computing in Medicine”, P. J. Petel, ed., pp. 126–134.Google Scholar
  15. Kitney, R. I., 1984, New findings in the analysis of heart rate variability in infants, Automedica, 4:289–310.Google Scholar
  16. Kitney, R. I., Linkens, D. A., Selman, A. C., and McDonald, A. H., 1982, The interaction between heart rate and respiration: Part 2 — nonlinear analysis on computer modelling, Automedica, 4:141–153.Google Scholar
  17. Kitney, R. I., Byrne, S., Edmonds, M. E., Watkins, P. J., and Roberts, V. C., 1982b, Heart rate variability in the assessment of autonomic diabetic neuropathy, Automedica, 4:155–167.Google Scholar
  18. Linkens, D. A., 1979a, Theoretical analysis of beating and modulation phenomena in weakly intercoupled van der Pol oscillator systems for biological mdoelling, J. Theoret. Biol., 79:31–54.CrossRefGoogle Scholar
  19. Linkens, D. A., 1979b, Modulation analysis of forced nonlinear oscillations for biological modelling, J. Theoret. Biol., 77:235–251.CrossRefGoogle Scholar
  20. Lloyd-Mostyn, R. H., and Watkins, P. J., 1976, Total cardiac denervation in diabetic autonomic neuropathy, Diabetics, 25:748–751.CrossRefGoogle Scholar
  21. Mackay, J. D., 1983, Respiratory sinus arrhythmia in diabetic neuropathy, Diabetologia, 24:253.PubMedCrossRefGoogle Scholar
  22. Nugent, S. T., and Finlay, J. P., 1983, Spectral analysis of periodic and normal breathing in infants, IEEE Trans. Biomedical Engineering, BME-30, 10:672–675, October 1983.CrossRefGoogle Scholar
  23. Sayers, B. McA., 1973, Analysis of heart rate variability, Ergonomics, 16:17–32.PubMedCrossRefGoogle Scholar
  24. Sayers, B. McA., 1980, Signal analysis of heart rate variability, in: “The Study of Heart Rate Variability”, R. I. Kitney and O. Rompelman, eds., Clarendon Press, Oxford.Google Scholar
  25. Southall, D. P. et al., 1983, First report on the combined study of SIDS, Br. Med. J., 286:1092–1096.CrossRefGoogle Scholar
  26. Watkins, P. J., and Mackay, J. D., 1980, Cardiac denervation in diabetic neuropathy, Ann. Internal Med., 92 (Part 2):304–307.Google Scholar
  27. Wheeler, T., and Watkins, P. J., 1973, Cardiac denervation in diabetics, Br. Med. J., 4:584–586.PubMedCrossRefGoogle Scholar
  28. Wieling, W., van Brederode, J. F. M., de Rijk, Borst, L. G., and Dunning, A. J., 1982, Reflex control of heart rate in normal subjects in relation to age: a data base for cardiac vagal neuropathy, Diabetologia, 22:163–166.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • R. I. Kitney
    • 1
  1. 1.Engineering in Medicine Laboratory, Department of Electrical EngineeringImperial CollegeLondonUK

Personalised recommendations