Abstract
In the spirit of a workshop, I will discuss possibilities of there being two independent mechanisms for the entry of lipids into the myelin sheath. These proposed mechanisms would work separately, though not necessarily independently, to deploy different lipids in the cytoplasmic and external sides, respectively, of the ‘asymmetric’ bilayer membrane. Before elaborating on these mechanisms, I will discuss pertinent material under six topics: (1) need for myelin, (2) myelin lipid composition, (3) dynamics of myelin lipids, (4) metabolism of sphingomyelin, ethanolamine plasmalogen, phosphatidylserine and phosphatidylinositol 4,5-bisphosphate, (5) cholesterol metabolism and (6) glycolipid metabolism. The strategies used to provide myelin with the abovementioned phospholipids, with cholesterol and with glycolipids will then be integrated with our current picture of myelin protein assembly (e.g. Colman et al., this volume). The relatedness of the dual mechanisms for proteins and lipids will be stressed. One mechanism involves the Golgi apparatus as the sorting station for integral proteins (as proteolipid protein and P0) and certain glycolipids to the external leaflet. The other mechanism is based at (or near) the plasma membrane or in adjacent myelin, to rapidly sequester myelin basic proteins and certain phospholipids into the cytoplasmic face of compact myelin.
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References
Baranska, J., 1982, Biosynthesis and transport of phosphatidylserine in the cell, Adv. Lipid Res., 19: 163.
Barenholz, Y. and Thompson, T. E., 1980, Sphingomyelin in bilayers and biological membranes, Biochim. Biophys. Acta, 604: 129.
Benjamins, J. A., Iwata, R., and Hazlett, 1978, Kinetics of entry of proteins into the myelin membrane, J. Neurochem., 31: 1077.
Benjamins, J. A. and Smith, M. E., 1984, Metabolism of Myelin, in: “Myelin”, 2nd Ed., P. Morell, ed., Plenum Press, New York.
Berridge, M. J. and Irvine, R. F., 1984, Inositol trisphosphate, a novel second messenger in cellular signal transduction, Nature, 312: 315.
Boggs, J. M. and Moscarello, M. A., 1978, Structural organization of the human membrane, Biochim. Biophys. Acta, 515: 1.
Boggs, J. M., Chia, L. S., Rangaraj, G., and Moscarello, M., 1986, Interaction of myelin basic protein with different ionization states of phosphatidic acid and phosphatidylserine, Chem. Phys. Lipids, 39: 164.
Braun, P. E., 1984, Molecular Organization of Myelin, in: “Myelin”, 2nd Ed., P. Morell, ed., Plenum Press, New York.
Burgisser, P., Matthieu, J.-M., Jeserich, G., and Waehneldt, T. V, 1986, Myelin lipids: A phylogenetic study, Neurochem. Res., 11: 1261.
Clarke, N. G. and Dawson, R. M. C., 1981, Alkaline 0 N transacylation. A new method for the quantitative deacylation of phospholipids, Biochem. J., 195: 301.
Clejan, S. and Bittman, R., 1984, Decreases in rates of lipid exchange between mycoplasma gallisepticom cells and unilamellar vesicles by incorporation of sphingomyelin, J. Biol. Chem., 259: 10823.
Chou, K. H., Ilyas, A. A., Evans, J. E., and Quarles, R. H., 1985, Structure of a glycolipid reacting with monoclonal IgM in neuropathy and with HNK-1, Biochem. Biophys. Res. Commun., 128: 383.
Coleman, R. A. and Bell, R. M., 1983, Topography of membrane-bound enzymes that metabolize complex lipids, in: “The Enzymes”, 3rd Ed., Vol. XVI, P. D. Boyer, ed., Academic Press, New York.
Dawson, R. M. C., 1985, Enzymic pathways of phospholipids in the nervous system, in: “Phospholipids in Nervous Tissues”, J. Eichberg, ed., John Wiley and Sons, New York.
Deshmukh, D. S., Bear, W. D., and Brockerhoff, H., 1978, Polyphosphoinositide biosynthesis in three subfractions of rat brain myelin, J. Neurochem., 30: 1191.
Diringer, H., Marggaf, W. D., Koch, M. A., and Anderer, F. A., 1972, Evidence for a new biosynthesis pathway of sphingomyelin in SV 40 transformed mouse cells, Biochem. Biophys. Res. Commun., 47: 1345.
Finean, J. B. and Michell, R. H., 1981, Isolation, composition and general structure of membranes, in: “Membrane Structure”, J. B. Finean and R. H. Michell, eds., Elsevier/North-Holland Biomedical Press, Amsterdam, Holland.
Gould, R. M., Matsumoto, D., and Mattingly, G., 1982, The Schwann Cell, in: “Handbook of Neurochemistry”, 2nd Ed., Vol. 1, A. Lajtha, ed., Plenum Press, New York.
Gould, R. M. and Dawson, R. M. C., 1976, Incorporation of newly-formed lecithin into peripheral nerve myelin, J. Cell Biol., 68: 480.
Gould, R. M., 1985, Myelin Development, in: “Developmental Neurochemistry”, R. C. Wiggins, D. W. McCandless, and S. J. Enna, eds., Univ. Of Texas Press, Austin, TX.
Gould, R. M., Connell, F., and Spivack, W. D., 1987a, Phospholipid metabolism in mouse sciatic nerve in vivo: possible relevance to myelination, J. Neurochem., 48: 853.
Gould, R. M., Holshek, J., Silverman, W. D., and Spivack, W. D., 1987b, Localization of phospholipid synthesis to Schwann cells and axons, J. Neurochem., 48: 1121.
Hedley-Whyte, E. T., Rawlins, F. A., Salpeter, M. M., and Uzman, B. G., 1969, Distribution of cholesterol 1,2-H during maturation of mouse peripheral nerve, Lab. Invest., 21: 536.
Hedley-Whyte, E. T., 1975, Distribution of [l,2-3H] cholesterol in mouse brain after injection in the suckling period, J. Cell Biol., 66: 333.
Holtzman, E. and Mercurio, A. M., 1980, Membrane circulation in neurons and photoreceptors: some unresolved issues. Int. Rev. Cytol., 67: 1.
Irvine, R. F., 1982, The enzymology of stimulated inositol lipid turnover, Cell Calcium, 3: 295.
Kaplan, M. R. and Simoni, R. D., 1985, Transport of cholesterol from the endoplasmic reticulum to the plasma membrane, J. Cell Biol., 101: 446.
Kirschner, D. A., Ganser, A. L., and Caspar, D. L. D., 1984, Diffraction studies of molecular organization and membrane interactions in myelin, in: “Myelin”, 2nd Ed., P. Morell, ed., Plenum Press, N. Y.
Kishimoto, Y., 1983, Ceramides and cerebrosides, in: “Handbook of Neurochemistry”, 2nd Ed., Vol. 3, A. Lajtha, ed., Plenum Press, N. Y.
Konat, G., 1981, Intracellular translocation of newly synthesized myelin proteins in the rat brain stem slices, Exp. Neurol., 73: 254.
Kuffler, S. W., Nicholls, J. G., and Martin, A. R., 1984, in: “From Neuron to Brain”, 2nd Ed., Sinhauer Associates, Sunderland, MA.
Lange, Y. and Steck, T., 1985, Cholesterol-rich intracellular membranes: A precursor to the plasma membrane, J. Biol. Chem., 260: 15592.
Ledeen, R. W., 1979, Structure and distribution of gangliosides, in: “Complex Carbohydrates of Nervous Tissue”, R. U. Margolis and R. K. Margolis, eds. Plenum Press, New York.
Ledeen, R. W., 1984, Lipid-metabolizing enzymes of myelin and their relation to the axons, J. Lipid Res., 25: 1548.
Lipsky, N. G. and Pagano, R. E., 1985, Intracellular translocation of fluorescent sphingolipids in cultured fibroblasts: endogenously synthesized sphingomyelin and glucocerebroside analogues pass through the Golgi apparatus en route to the plasma membrane, J. Cell Biol., 100: 27.
London, Y., Demel, R. A., Van Kessel, G., Zahler, W. S. M., and Van Deenen, L. L. M., 1974, The interaction of the “Folch-Lees” protein with lipids at the air-water interface, Biochim. Biophys. Acta, 332: 69.
Malgat, M., Maurice, A., and Baraud, J., 1986, Sphingomyelin and ceramide-phosphoethanolamine synthesis by microsomes and plasma membranes from rat liver and brain, J. Lipid Res., 27: 251.
Marggraf, W. D., Anderer, F. A., and Kanfer, J. N., 1981, The formation of sphingomyelin from phosphatidylcholine in plasma membrane preparations from mouse fibroblasts, Biochim. Biophys. Acta, 664: 61.
Marggraf, W. D., Zertani, R., Anderer, F. A., and Kanfer, J. N., 1982, The role of endogenous phosphatidylcholine and ceramide in the biosynthesis of sphingomyelin in mouse fibroblasts, Biochim. Biophys. Acta, 710: 314.
Morell, P. and Toews, A. D., 1984, In vivo metabolism of oligodendroglial lipids, Adv. Neurochem., 5: 47.
Neskovic, N. M., Roussel, G., and Nussbaum, J. L., 1986, UDP galactose: ceramide galactosyltransferase of rat brain: A new method of purification and production of specific antibodies, J. Neurochem., 47: 1412.
Nishizuka, Y., 1984, The role of protein kinase C in cell surface signal transduction and tumour promotion, Nature, 308: 693.
Norton, W. T., 1981, Formation, structure and biochemistry of myelin, in: “Basic Neurochemistry”, G. J. Siegel, R. W. Albers, B. W. Agranoff and R. Katzman, eds., Little Brown and Co., Boston.
Norton, W. T. and Cammer, W., 1984, Isolation and characterization of myelin, in: “Myelin”, 2nd Ed., P. Morell, ed., Plenum Press, New York.
Palmer, F. B. and Dawson, R. M. C., 1969, Complex formation between triphos-phoinoisitide and experimental allergic encephalitogenic protein, Biochem. J., 11: 637.
Patton, S., 1970, Correlative relationship of cholesterol and sphingomyelin in cell membranes, J. Theor. Biol., 29: 489.
Palech, S. L. and Vance, D. E., 1984, Regulation of phosphatidylcholine biosynthesis, Biochim. Biophys. Acta, 779: 217.
Radin, N. S., 1983, Sulfatides, in: “Handbook of Neurochemistry”, 2nd Ed., Vol. 3, A. Lajtha, ed., Plenum Press, New York.
Rawlins, F. A., 1973, A time-sequence autoradiographic study of the in vivo incorporation of 1,2-3H of cholesterol into peripheral nerve myelin, J. Cell Biol., 58: 42.
Ritchie, J. M., 1984, Physiological basis of conduction in myelinated nerve fibers, in: “Myelin”, 2nd Ed., P. Morell, ed., Plenum Press, N.Y.
Smith, M. E., 1973, A regional survey of myelin development: some compositional and metabolic aspects, J. Lipid Res., 15: 541.
Stoner, G. L., 1984, Predicted folding of structure in myelin basic proteins, J. Neurochem., 43: 433.
Sun, G. Y. and Foudin, L. L., 1983, Phospholipid composition and metabolism in the developing and aging nervous system, in: “Phospholipids in Nervous Tissues”, J. Eichberg, ed., John Wiley and Sons, N.Y.
Tennekoon, G., Zaruba, M., and Wolinsky, J., 1983, Topography of cerebroside sulfotransferase in Golgi-enriched vesicles from rat brain, J. Cell Biol., 97: 1107.
van den Hill, A., van Heusden, G. P. H., and Wirtz, K. W. A., 1985, The synthesis of sphingomyelin in the Morris hepatomas 7777 and 5123 D is restricted to the plasma membrane, Biochim. Biophys. Acta, 833: 354.
Voelker, D. R. and Kennedy, E. P., 1983, Phospholipid exchange protein-dependent synthesis of sphingomyelin, Methods Enzymol., 98: 596.
Webster, H. de F., 1971, The geometry of peripheral myelin sheaths during their formation and growth in rat sciatic nerve, J. Cell Biol., 48: 348.
Wiggins, R. C., Benjamins, J. A., and Morell, P., 1975, Appearance of myelin proteins in rat sciatic nerve during development, Brain Res., 89: 99.
Yao, J. K., 1984, Lipid composition of normal and degenerating nerve, in: “Peripheral Neuropathies”, 2nd Ed., Vol. 1, P. J. Dyck, P. K. Thomas, E. H. Lambert and R. Bunge, eds, W. B. Saunders Co., Philadelphia.
Zilversmit, D. B., 1984, Lipid transfer proteins, J. Lipid Res., 25: 1563.
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Gould, R.M., Spivack, W., Cataneo, R., Holshek, J., Konat, G. (1987). Lipids and Myelination. In: Crescenzi, G.S. (eds) A Multidisciplinary Approach to Myelin Diseases. NATO ASI Series, vol 142. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0354-2_7
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