Myelin Associated Glycoprotein and 2’, 3’ Cyclic Nucleotide 3’-Phosphodiesterase During Development and in Dysmyelinating Mutants
Considerable investigative effort has been focused on the two protein classes, myelin basic protein (MBP) and proteolipid proteins (PLP), that are quantitatively most prominent in myelin and that are certainly important components of the structural matrix throughout the myelin sheath. We would like now to draw attention to two quantitatively minor proteins of myelin, 2′, 3′ cyclic nucleotide 3′-phosphodiesterase (CNP) and myelin associated glycoprotein (MAG), that are expressed developmentally in oligodendrocytes prior to PLP and MBP, and may play important roles at early stages of myelinogenesis. They are also present in the myelin sheath, possibly in discrete compartments where their function could be different from that of PLP and MBP.
KeywordsMyelin Basic Protein Myelin Sheath Cyclic Nucleotide Myelin Protein Cyanogen Bromide
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