The Effects of Hypoxia on Oligodendrocytes in Primary Mouse CNS Cell Cultures
In human infants hypoxia is one of the chief perinatal factors resulting in subsequent brain damage (Behrman and Vaughan, 1983) but very little is known about the neurochemical effects of hypoxia. During the major period of rapid CNS myelination a major part of the brains protein and lipid synthetic capacity is involved in myelinogenesis. Thus any metabolic insult during this vulnerable period may lead to a preferential reduction in myelin production. Cerebral demyelination is also known to occur after cases of severe hypoxia in adults (Ginsberg et al., 1974).
KeywordsMyelin Basic Protein Regeneration Period Mixed Glial Culture Hypoxic Stimulus Neuroactive Amino Acid
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