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The Effects of Hypoxia on Oligodendrocytes in Primary Mouse CNS Cell Cultures

  • N. Herschkowitz
  • R. Reynolds
  • E. Bossi
Part of the NATO ASI Series book series (NSSA, volume 142)

Abstract

In human infants hypoxia is one of the chief perinatal factors resulting in subsequent brain damage (Behrman and Vaughan, 1983) but very little is known about the neurochemical effects of hypoxia. During the major period of rapid CNS myelination a major part of the brains protein and lipid synthetic capacity is involved in myelinogenesis. Thus any metabolic insult during this vulnerable period may lead to a preferential reduction in myelin production. Cerebral demyelination is also known to occur after cases of severe hypoxia in adults (Ginsberg et al., 1974).

Keywords

Myelin Basic Protein Regeneration Period Mixed Glial Culture Hypoxic Stimulus Neuroactive Amino Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • N. Herschkowitz
    • 1
    • 2
  • R. Reynolds
    • 1
    • 2
  • E. Bossi
    • 1
    • 2
  1. 1.Department of PediatricsUniversity of BernBernSwitzerland
  2. 2.Department of BiochemistryImperial College LondonLondonEngland

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