Abstract
The potential for recovery from central nervous system disease has generated great interest in CNS regeneration. In demyelinating diseases, remyelination has been more extensively studied than in the past in view of the possibility for enhancing healing. Similary the post-development brain has been shown to be far more plastic than was previously believed in terms of its capacity for regeneration and proliferation. Some of the evidence for oligodendrocyte proliferation and its role in remyelination will be reviewed in this paper.
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References
E. K. Adrian, Jr. M. G. Williams and F. C. George, Fine structure of reactive cells in injured nervous tissue labeled with H-thimidine injected before injury, J. Comp. Neurol., 180: 815–840 (1978).
A. J. Aguayo, G. M. Bray and S. C. Perkins, Axon-Schwann cell relationships in neuropathies of mutant mice, Ann. N.Y. Acad. Sci., 317: 512–531 (1979).
L. S. Arenella and R. M. Herndon, Mature oligodendrocutes. Division following experimental demyelination in adult animals, Arch. Neurol., 41: 1162–1165 (1984).
W. F. Blakemore, Observations on remyelination in the rabbit spinal cord following demyelination induced by lysolecithin, Neurophatol. Appl. Neurobiol., 4: 47–59 (1978).
W. F. Blakemore, Limited remyelination of CNS axons by transplanted Schwann cells, Neuropathol. Appl. Neurobiol., 11: 73 (1985).
L. Bologa, J. C. Bisconte, R. Jourbert, P. J. Marangos, C. Derbin, F. Rioux, and N. Herschkowitz, Accelerated differentiation of oligodendrocytes in neuronal-rich embryonic mouse cultures, Brain Res., 252: 129–136 (1982).
L. Bologa, A. Z’Gragger, E. Rossi and N. Herschkowitz, Differentiation and proliferation: two possible mechanisms for the regeneration of oligodendrocytes in culture, J. Neurol. Sci., 57: 419–434 (1982).
D. Cassel, P. M. Wood, R. P. Bunge and L. Glaser, Mitogenicity of brain axolemma membranes and soluble factors for dorsal root ganglion Schwann cell, J. Cell. Biochem., 18: 433–445 (1982).
M. C. Dal Canto and R. L. Barbano, Remyelination during remission in Theiler’s virus infection, Am. J. Pathol., 116: 30–45 (1984).
I. D. Duncan, A. J. Aguayo, R. P. Bunge and R. P. Wood, Transplantation of rat Schwann cells grown in tissue culture into the mouse spinal cord, J. Neurol. Sci., 49: 241–252 (1981).
E. D. Friedman, G. Nilaver, M. Perlow, P. Carmel and N. Latov, Expression of myelin basic protein immunoreactivity in shiverer mice following intracerebral fetal cortical implants, Anat. Rec., 211: 64a (1985).
V. L. Friedrich and N. H. Sternberger, Dividing oligodendrocyte precursors do not stain for myelin basic protein, Soc. Neurosci. Abstr., 10: 81 (1984).
J. Fulcrand, J. Valat and A. Privat, Myelination gliosis and reactive gliosis in the developing optic nerve of the rat, Reprod. Nutrit. Develop., 22: 11–178 (1982).
D. Giulian et al., Peptides from regenerating C.N.S. promote specific populations of macroglia, Proc. Natl. Acad. Sci., 82: 4287 (1985).
M. Gumperl and N. Baumann, Central nervous sistem myelination and remyelination by brain transplants, in: “Glial-neuronal Comunication in development and regeneration”, H. Althaus, W. Seifert, eds, Plenum Press, New York (1986).
B. M. Harrison, Remyelination in the central nervous system, in: “Multiple Sclerosis”, J. F. Hallpike, C. W. M. Adams and W. Tourtellotte, eds, Williams and Wilkins, Baltimore, 461–478 (1983).
B. K. Hartman, H. C. Agrawal, D. Agrawal and S. Kalmbach, Development and maturation of central nervous system myelin: Comparison of immunohistochemical localization of proteolipid protein and basic protein in myelin and oligodendrocytes, Proc. Natl. Acad. Sci. U.S.A., 9: 4217–4220 (1982).
R. M. Herndon, D. L. Price and L. P. Weiner, Regeneration of oligodendroglia during recovery from demyelinating disease, Science, 195: 693–694 (1977).
K. Imamoto, J. Paterson and C. P. LeBlond, Radioautographic investigation of gliogenesis in the corpus callosum of young rats. I. Sequential changes in oligodendrocytes, J. Comp. Neurol., 180: 115–128, 132-137 (1978).
E. S. Johnson and S. K. Ludwin, The demonstration of recurrent demyelination and remyelination of axons in the central nervous system, Acta Neuropath., 53: 93–98 (1981).
T. Kitamura, Y. Tsuchihashi and S. Fujita, Initial response of silver-impregnated “resting microglia” to stab wounding in rabbit hippocampus, Acta Neuropath., 44: 31–39 (1978).
N. Latov, G. Nilaver, E. A. Zimmerman, W. G. Johnson, A. J. Silverman, R. Defendi and L. Cote, Fibrillary astrocytes proliferate in response to brain injury. A study combining immunoperoxidase technique glial fibrillary acidic protein and radioantography of tritiated thymidine, Develop. Biol., 2: 381–384 (1979).
G. E. Lemke and G. P. Brockes, Glial growth factor: a mitogenic polypeptide of the brain and pituitary, Fed. Proc., 42: 2627–2629 (1983).
S. K. Ludwin, Central nervous system demyelination and remyelination in the mouse. An ultrastructural study of Cuprizone toxicity, Lab. Invest., 39: 597–612 (1978).
S. K. Ludwin, An autoradiographic study of cellular proliferation in remyelination of the central nervous system, Am. J. Path., 95: 683–690 (1979).
S. K. Ludwin, Chronic demyelination inhibits remyelination in the central nervous system. An analysis of contributing factors, Lab. Invest., 43: 382–387 (1980).
S. K. Ludwin, Pathology of demyelination and remyelination, in: “Demyelinating Disease: Basic and Clinical Electrophysiology”, S. G. Waxman and J. M. Ritchie, eds, Raven Press, New York, 123–168 (1981).
S. K. Ludwin, Proliferation of oligodendrocytes following trauma to the central nervous system, Nature (Lond), 308: 274 (1984a).
S. K. Ludwin, The function of perineuronal satellite oligodendrocytes: An immunohistochemical study, Neuropath. Appl. Neurobiol., 10: 143–149 (1984b).
S. K. Ludwin, The reaction of oligodendrocytes and astrocytes to trauma and implantation: A combined autoradiographic and immunohistochemical study, Lab. Invest., 52: 20–30 (1985).
S. K. Ludwin and M. Maitland, Long term remyelination fails to reconstitute normal thickness of central myelin sheaths, J. Neurol. Sci., 64: 193–198 (1984).
S. K. Ludwin and N. H. Sternberger, An immunochemical study of myelin proteins during demyelination and remyelination, Acta Neuropathol., 63: 240–248 (1984).
L. Manuelidis and E. E. Manuelidis, An autoradiographic study of the proliferation and differentiation of glial cells in vitro, Acta Neuropath., 18: 193–213 (1971).
D. L. Meinecke, H.de F. Webster, Fine structure of diving astroglia and oligodendroglia during myelin formation in the developing mouse spinal cord, J. Comp. Neurol., 222: 47–55 (1984).
J. E. Merril, S. Kutsunai, C. Mohlstrom, F. Hofman, J. Groopman and D. W. Golde, Proliferation of astroglia and oligodendroglia in response to human T cell-derived factors, Science, 224: 1428–1430 (1984).
S. Mori, Uptake of H thymidine by corpus callosum cells in rats following a stab wound of the brain, Brain Res., 46: 177–186 (1972).
S. Mori and C. P. LeBlond, Electron microscopic identification of three classes of oligodendrocytes and a preliminary study of their proliferative activity in the corpus callosum of young rats, J. Comp. Neurol., 139: 1–80 (1970).
J. A. Paterson, Postnatal development of oligodendrocytes, in: “Eleventh International Congress of Anatomy: Glial and Neuronal Cell Biology”, E. Acosta Vidrio, S. Fedoroff, eds., Alan R. Liss, New York, 83–92 (1981).
J. A. Paterson, Dividing and newly produced cells in the corpus callosum of adult mouse cerebrum as detected by light microscopic radioautography, Anat. Anzeig., (Jena), 153: 149–168 (1983).
B. Pettmann, J-P. Delaunoy, J. Courageot, G. Devilliers and M. Sensenbrenner, Rat brain cells in culture: Effects of brain extracts on the development of oligodendroglia-like cells, Develop. Biol., 75: 278–287 (1980).
J. W. Prineas and F. Connell, Remyelination in multiple sclerosis, Ann. Neurol., 5: 22–31 (1979).
J. W. Prineas, The neuropathology of multiple sclerosis, in: “Handbook of Clinical Neurology”, Koetsier, ed., Elsevier Science Publishers, Amsterdam, 213–257 (1985).
J. W. Prineas, E. E. Kwon, E. S. Cho, L. R. Sharer, Continual breakdown and regeneration of myelin in progressive multiple sclerosis plaques, Ann. N.Y. Acad. Sci., 436: 111–32 (1984).
A. Privat, J. Valat and J. Fulcrand, Proliferation of neuroglial cell lines in the degenerating optic nerve of young rats. A radioautographic study, J. Neuropath. Exper. Neurol., 40: 46–60 (1981a).
A. Privat, J. Valat, F. Lachapelle, N. Baumann and J. Fulcrand, Radioautographic evidence for the protracted proliferation of glial cells in the central nervous system of jimpy mice, Brain Res., 248: 19–31 (1981b).
M. C. Raff, R. H. Miller, and M. Noble, A glial progenitor cell that develops in vitro into an astrocyte or an oligodendrocyte depending on culture medium, Nature (Lond)., 303: 390–396 (1983).
M. C. Raff, E. R. Abney, J. Sok-Scang, Reconstitution of a developmental clock in vitro: a critical role for astrocytes in the timing of oligodendrocyte differentiation, Cell, 42: 61–69 (1985).
C. S. Raine and U. Traugott, Remyelination in chronic relapsing experimental allergic encephalomyelitis and multiple sclerosis, in: “The Pathology of the Myelinated Axon”, M. Adachi, A. Hiron, S. M. Aronson, eds., Igaki-Shoin, Tokyo, 229–275 (1985).
C. S. Raine, L. Scheinberg and J. M. Waltz, Multiple Sclerosis. Oligodendrocyte survival and proliferation in an active established lesion, Lab. Invest., 45: 534–546 (1981).
M. Sensenbrenner, J-P. Delaunoy, G. Labourdette and B. Pettmann, Effects of brain extracts on the proliferation and the maturation of astroglial and oligodendroglial cells in culture, Biochem. Soc. Transact., 10: 424–426 (1982).
D. L. Simpson, R. Morrison, J. De Vellis and H. R. Herschwan, Epidermal growth factor binding and mitogenic activity on purified populations of cells from the central nervous system, J. Neurosci. Res., 8: 453–462 (1982).
R. P. Skoff, Increased proliferation of oligodendrocytes in the hypomyelinated mouse mutant-jimpy, Brain Res., 248: 19–31 (1982).
R. P. Skoff, D. L. Price and A. Stocks, Electron microscopic autoradiographic studies of gliogenesis in rat optic nerve. I. Cell Proliferation, J. Comp. Neurol., 169: 291–312 (1976).
N. H. Sternberger, Y. Itoyama, M. W. Kies and H. deF. Webster, Myelin basic protein demonstrated immunocytochemically in oligodendroglia prior to myelin sheath formation, Proc. Nat. Acad. Sci. USA, 75: 2521–2524 (1978b).
N. H. Sternberger, R. H. Quarles, Y. Itoyama and H. deF. Webster, Myelin-associated glycoprotein demonstrated immunocytochemically in myelin and myelin-forming cells of developing rat, Proc. Nat. Acad. Sci., 76: 1510–1514 (1979).
R. R. Sturrock and D. A. Mcrae, Mitotic division of oligodendrocytes which have begun myelination, J. Anat., 131: 577–582 (1980).
R. R. Sturrock, Electron microscopic evidence for mitotic division of oligodendrocytes, J. Anat., 132: 429–432 (1981).
I. Tennekoon, Y. Kishimoto, I. Singh, G. Nonaka, J-M. Bourre, The differentiation of oligodendrocytes in the rat optic nerve, Develop. Biol., 79: 149–158 (1980).
P. Willis, M. Berry, A. C. Richres, Effects of trauma on cell production in the subependymal layer of the rat neocortex, Neuropath. Appl. Neurobiol., 2: 377–388 (1976).
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Ludwin, S.K. (1987). Proliferation of Oligodendrocytes and Remyelination. In: Crescenzi, G.S. (eds) A Multidisciplinary Approach to Myelin Diseases. NATO ASI Series, vol 142. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0354-2_29
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DOI: https://doi.org/10.1007/978-1-4757-0354-2_29
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