Neurochemical Changes in White Matter of Patients with Alzheimer’s Disease
Most of the elderly persons with dementia belong to a group with changes in the brain which are considered characteristic for Alzheimer’s disease. It was in 1907 that Alzheimer described the autopsy findings in a woman who died at 55 with progressive dementia and in whom abnormal nerve cells contained tangles of fibers (neurofibrillary tangles) and clusters of degenerating nerve endings (neuritic plaques) in the cerebral cortex. This condition was then considered to be Alzheimer’s disease a cause of presenile dementia (AD). For many decades Alzheimer’s disease was considered an entity clearly delineated from the more common disease senile dementia, although similar microscopical changes occurred in the two categories. In the early I960’s Kidd (1963) and Terry et al. (1964) demonstrated identical ultrastructural changes in the brains of elderly persons with presenile and senile dementia and since then also senile dementia has been included in the entity Alzheimer’s disease (AD/SDAT).
KeywordsWhite Matter Sialic Acid Neurofibrillary Tangle Senile Dementia Neuritic Plaque
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