Cerbrospinal Fluid Markers in Multiple Sclerosis
We have been concerned for many years in research work regarding cere-brospinal fluid (CSF) markers of pathological events that happen during the course of multiple sclerosis (MS), and, in particular, during the acute phases of the disease (1,2,3). If one considers how difficult it is to obtain biopsy specimens of the central nervous system (CNS) in MS patients, and that autopsic specimens are not always indicative of the evolution of the lesion during the time, the study of the CSF proteins can provide us with an available tool for monitoring very important pathological events such as demyelination, immunitary reaction, glial activity, remyelination. All these events are of the greatest interest both for researches into the pathogenesis of the disease and for the clinical study of the patient.
KeywordsMultiple Sclerosis Glial Fibrillary Acidic Protein Myelin Basic Protein Glial Activity Multiple Sclerosis Plaque
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