Antigenic and Functional Characteristics of a Bipotential Glial Progenitor Cell in Rat Cerebellar Primary Cultures
The processes of repair and remyelination in the CNS depend, among others, on the availability of cells of the oligodendrocytic lineage capable of proliferating and of expressing a differentiated oligodendroglial phenotype. Such cells could be either mature oligodendrocytes (1) or oligodendrocyte precursors (see ref. 2 for review), which might respond to growth factors released in the lesioned brain (3) or to T-cell derived lymphokines (4). The existence of oligodendrocyte progenitor cells in the mature brain has been object of long debates, which can be largely attributed to the difficulty of identifying these cells when they still lack cell-type-specific markers such as myelin basic protein or galactocerebroside (see ref. 2). Recently, bipotential oligodendrocyte-type-2 astrocyte precursors (5) have been isolated from the central white matter of adult rats and allowed to differentiate in vitro (6). This finding strongly suggests that undifferentiate oligodendrocyte precursors do exist in the mature CNS.
KeywordsGlial Fibrillary Acidic Protein Chondroitin Sulfate Kainic Acid Proteoglycan Chondroitin Sulfate Mature Oligodendrocyte
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