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Myelinogenesis in Primary Cultures

  • L. L. Sarliève
Part of the NATO ASI Series book series (NSSA, volume 142)

Abstract

The formation and growth of myelin sheaths is a prominent part of neural development. Periods of age of accelerated development that are characterized by increased sensibility and external environmental influences have been identified during brain development (1). For example, in rat and mouse, the critical period during which thyroid hormones influence brain development is associated, among other events, with rapid myelinogenesis which occurs in both species during the tenth and 30th day after birth (2). During this period, striking morphological and biochemical changes have been described. The biochemical parameters which seem best to measure this temporal changes are the enzymes and compounds most closely associated with myelination. Cerebrosides (3,4), galactosyl glycerol lipids (5), sulfatides (3), sulfogalactosyl glycerol lipids (6), and the enzymes catalyzing their synthesis (5, 7–9,6) the myelin basic protein (10, 11), myelin proteolipid protein (PLP) (12,13) or a synthetic polypeptide composed of the C-terminal amino acids of the PLP sequence (14), Wolfgram protein (10), 2′, 3′-cyclicnucleotide phosphohydrolase (CNP) (15) and pH 7.2 cholesterol ester hydrolase (16) are very useful molecular markers of myelination (for an extensive review, see Ref. 17).

Keywords

Myelin Basic Protein Embryonic Mouse Myelin Formation Cholesterol Ester Hydrolase Glial Cell Culture 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • L. L. Sarliève
    • 1
  1. 1.Centre de Neurochimie du CNRS and U.44 de l’INSERMStrasbourg CedexFrance

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