The PP Cell

  • Enrico Solcia
  • Carlo Capella
  • Luciana Usellini
  • Roberto Fiocca
  • Fausto Sessa


The first evidence for the existence in mammalian pancreatic islets of a fourth type of endocrine cell, besides A, B, and D cells, was provided by Bencosme and Liepa1 who detected in the dog and cat uncinate process a type of cell (the “X” cell) showing distinctive staining patterns with trichrome methods. Subsequently, this cell, relabeled “F cell,” was also shown to display distinctive ultrastructural features, i.e., fairly large secretory granules of round to angular shape and variable, often poor density.2 No ultrastructurally similar cells were detected in the pancreas of other mammals, including the rabbit, rat, and guinea pig. However, a fourth type of endocrine cell, the so-called D1 cel13 showing small round granules obviously different from those of A, B, and D cells, was described in the human islets.4–6


Chronic Pancreatitis Endocrine Cell Pancreatic Polypeptide Human Pancreas Ventral Lobe 
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Copyright information

© Plenum Publishing Corporation 1985

Authors and Affiliations

  • Enrico Solcia
    • 1
  • Carlo Capella
    • 2
  • Luciana Usellini
    • 3
  • Roberto Fiocca
    • 1
  • Fausto Sessa
    • 1
  1. 1.Department of Human PathologyUniversity of PaviaPaviaItaly
  2. 2.Department of Human Pathology and Histopathology, Histochemistry, and Ultrastructure Research CenterUniversity of PaviaPaviaItaly
  3. 3.Histopathology, Histochemistry, and Ultrastructure Research CenterUniversity of PaviaPaviaItaly

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