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Histology, Cell Types, and Functional Correlation of Islets of Langerhans

  • Bruno W. Volk
  • Klaus F. Wellmann

Abstract

The pancreatic islets, first described in 1869 by Langerhans1 are compact round, ovoid, or less regular groups of polygonal epithelial cells irregularly distributed within the lobules of the exocrine portion of the organ (Fig. 1). The question as to whether or not the islets are surrounded by a connective tissue capsule has received a good deal of attention, mainly because of its presumed importance for theories of transitions between exocrine and endocrine cells. The most extensive review of this problem is that of Kraus,2 who lists many of the earlier authors in the field as supposing the existence of a true capsule, but also quotes a nearly equal number as being opposed to that supposition. The present consensus, already intimated by Kraus and reflected in more recent reviews,3,4,15,44 appears to be that the islands are surrounded by a more or less complete “pseudocapsule” formed by connective tissue fibers that are continuous with those of the interstitial septa of the exocrine part of the pancreas. While there is a gradual increase in the amount of intra-and extrainsular connective tissue with advancing age,5 the formation of a true capsule around the islet does not occur in the healthy organ.

Keywords

Islet Cell Pancreatic Islet Pancreatic Polypeptide Insulin Content Functional Correlation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1985

Authors and Affiliations

  • Bruno W. Volk
    • 1
  • Klaus F. Wellmann
    • 2
  1. 1.Department of PathologyUniversity of California Irvine Medical CenterOrangeUSA
  2. 2.Department of PathologyState University of New York, Downstate Medical CenterBrooklynUSA

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