Islet Cell Tumors and the Ulcerogenic Syndrome

  • M. Michael Wolfe
  • James E. McGuigan


In 1955, Zollinger and Ellison described a syndrome characterized by a severe, often fatal, form of peptic ulcer, accompanied by marked gastric acid hypersecretion, and non-β islet cell tumors (gastrinomas) of the pancreas.1 A gastric acid secretagogue was extracted from these tumors in 1960.2 Subsequent biochemical isolation of gastrin from the tumors3 and detection of elevated serum gastrin concentrations by radioimmunoassay in patients with the Zollinger-Ellison syndrome4 established gastrin-secreting tumors as the hallmark of the disease.


Gastric Acid Duodenal Ulcer Gastric Acid Secretion Serum Gastrin Islet Cell Tumor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Publishing Corporation 1985

Authors and Affiliations

  • M. Michael Wolfe
    • 1
  • James E. McGuigan
    • 1
  1. 1.Division of Gastroenterology, Department of MedicineUniversity of Florida College of MedicineGainesvilleUSA

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