Advertisement

Immunology of Islet Cells

  • Edward R. Arquilla
  • David P. Stenger

Abstract

Interest in the immunology of pancreatic islets has been sparked by the numerous clinical and experimental observations that an autoimmune mechanism is centrally involved in the pathogenesis of type I diabetes. Although much of this evidence is reviewed by Gepts and LeCompte (Chapter 16, this volume), it will be necessary to discuss possible immune mechanisms involved in experimental and clinical type I diabetes in this chapter.

Keywords

Major Histocompatibility Complex Human Leukocyte Antigen Major Histocompatibility Complex Class Islet Cell Allograft Rejection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Bottazzo, G. F., Florin-Christensen, A., and Doniach, D.: Lancet, 2:1279, 1974.Google Scholar
  2. 2.
    Huang, S.-W., and MacLaren, N. K.: Science 192:64, 1976.PubMedGoogle Scholar
  3. 3.
    Anderson, O. O.: In: Secondary Diabetes: The Spectrum of the Diabetic Syndrome. Edited by S. Podolsky and M. Viswanathan. Raven Press, New York, 1980, p. 409.Google Scholar
  4. 4.
    Cudworth, A. G., and Gorsuch, A. N.: In: Diabetes Mellitus: Theory and Practice, 3rd Ed. Edited by M. Ellenberg and H. Rifkin. Med. Exam. Publ. Comp., New York, 1982, p. 505.Google Scholar
  5. 5.
    Brogren, C. H., and Lemmark, A.: J. Clin. Endocrinol. Metab. 11:409, 1982.Google Scholar
  6. 6.
    DeBray-Sachs, M., Sai, P., Boitard, C., Assan, R., and Hamburger, J.: Clin. Exp. Immunol 51:1, 1983.Google Scholar
  7. 7.
    Elder, M. E., and MacLaren, N. K.: J. Immunol 130:1723, 1983.PubMedGoogle Scholar
  8. 8.
    MacLaren, N. K., Elder, M. E., Robbins, V. W., and Riley, W. J.: Metabolism 32(Suppl. 1):92, 1983.PubMedGoogle Scholar
  9. 9.
    Dyrberg, T., Poussier, P., Nakhooda, A. F., Marliss, E. B., and Lemmark, A.: Metabolism 32(SuppL 1):87, 1983.PubMedGoogle Scholar
  10. 10.
    Koevary, S., Rossini, A., Stoller, W., Chick, W., and Williams, R. M.: Science 220:727, 1983.PubMedGoogle Scholar
  11. 11.
    Marliss, E. B.: Metabolism 32(Suppl. 1):1, 1983.PubMedGoogle Scholar
  12. 12.
    Lemmark, A., Kanatsuna, T., Patzelt, C., Diakoumis, K., Carroll, R., Rubenstein, A. H., and Steiner, D. F.: Diabetologia 19:445, 1980.Google Scholar
  13. 13.
    Baekkeskov, S., Kanatsuna, T., Klareskog, L., Nielsen, D. A., Petersen, P. A., Rubenstein, A. H., Steiner, D. F., and Lemmark, A.: Proc. Natl Acad Sei. USA 78:6456, 1981.Google Scholar
  14. 14.
    Dyrberg, T., Baekkeskov, S., and Lemmark, A.: J. Cell Biol 94:472, 1982.PubMedGoogle Scholar
  15. 15.
    Kanatsuna, T., Freedman, Z. R., Rubenstein, A. H., and Lemmark, A.: Clin. Exp. Immunol 47:85, 1982.PubMedGoogle Scholar
  16. 16.
    Baekkeskov, S., Nielsen, J. H., Mamer, B., Bilde, T., Ludvigsson, J., and Lemmark, A.: Nature (London) 298:167, 1982.Google Scholar
  17. 17.
    Rouger, P., Goossens, D., Gane, P., and Salmon, C: Tissue Antigens 18:51, 1981.PubMedGoogle Scholar
  18. 18.
    Szulman, A. E.: Exp. Med 111:785, 1960.Google Scholar
  19. 19.
    Szulman, A. E.: J. Exp. Med 119:503, 1964.PubMedGoogle Scholar
  20. 20.
    Oriol, R., Cartron, J. P., Cartron, J., and Mulet, C.: Transplantation 29:184, 1980.PubMedGoogle Scholar
  21. 21.
    Gorer, P. A.: J. Pathol Bacteriol 47:231, 1938.Google Scholar
  22. 22.
    Gorer, P. A., Lyman, S., and Snell, G. D.: Proc. R. Soc. London Ser. B 135:499, 1948.Google Scholar
  23. 23.
    Klein, J., Figueroa, F., and Nagy, Z. A.: Annu. Rev. Immunol 1:119, 1983.PubMedGoogle Scholar
  24. 24.
    Klein, J.: In: The Mouse in Biomedical Research. Edited by H. L. Foster, J. D. Small, and J. G. Fox. Academic Press, New York, 1981, p. 119.Google Scholar
  25. 25.
    Miller, J. F. A. P., Vadas, M. A., Whitelaw, A., Gamble, J., and Bernard, C: J. Exp. Med. 145:1623, 1977.PubMedGoogle Scholar
  26. 26.
    Parr, E. L.: J. Exp. Med. 150:1, 1979.PubMedGoogle Scholar
  27. 27.
    Faustman, D., Hauptfeld, V., Davie, J. M., Lacy, P. E., and Shreffler, D. C: J. Exp. Med. 151:1563, 1980.PubMedGoogle Scholar
  28. 28.
    Parr, E. L.: Transplantation 27:45, 1979.PubMedGoogle Scholar
  29. 29.
    Kirby, W. N., and Parr, E. L.: J. Histochem. Cytochem. 27:746, 1979.PubMedGoogle Scholar
  30. 30.
    Parr, E. L., and Oei, J. S.: Tissue Antigens 3:99, 1973.PubMedGoogle Scholar
  31. 31.
    Thomson, N. M., Hancock, W. W., Lafferty, K. J., Kraft, N., and Atkins, R. C.: Transplant. Proc. 15:1373, 1983.Google Scholar
  32. 32.
    Hancock, W. W., Kraft, N., and Atkins, R. C.: Pathology 14:409, 1982.PubMedGoogle Scholar
  33. 33.
    Lafferty, K. J., Prowse, S. J., Simeonovic, C. J., and Warren, H. S.: Annu. Rev. Immunol 1:143, 1983.PubMedGoogle Scholar
  34. 34.
    Medawar, P. B.: In: The Immunologically Competent Cell: Its Nature and Origin. Edited by G. E. W. Wolstenholme and J. Knight. Churchill, London, 1963, p. 1.Google Scholar
  35. 35.
    Snell, G. D.: Annu. Rev. Microbiol 11:439, 1957.PubMedGoogle Scholar
  36. 36.
    Lacy, P. E., Davie, J. M., and Finke, E. H.: Transplantation 28:415, 1979.PubMedGoogle Scholar
  37. 37.
    Parr, E. L., Bowen, K. M., and Lafferty, K. J.: Transplantation 30:135, 1980.PubMedGoogle Scholar
  38. 38.
    Parr, E. L., and Lafferty, K. J.: Transplantation 30:142, 1980.PubMedGoogle Scholar
  39. 39.
    Okuda, K., David, C. S., and Shreffler, D. C: J. Exp. Med 146:1561, 1977.PubMedGoogle Scholar
  40. 40.
    Staines, N. A., Guy, K., and Davies, D. A. L.: Eur. J. Immunol, 5:n2, 1975.Google Scholar
  41. 41.
    McKenzie, L F. C, and Henning, M. M.: J. Exp. Med 147:61, 1978.Google Scholar
  42. 42.
    Gibofsky, A., Jaffe, E. A., Fotino, M., and Becker, C. G.: J. Immunol 115:730, 1975.PubMedGoogle Scholar
  43. 43.
    Fish, F., Staines, N. A., Sworn, J. L., and Davies, D. A. L.: Transplantation 22:551, 1976.PubMedGoogle Scholar
  44. 44.
    Parr, E. L., and McKenzie, L F. C: Immunogenetics 8:499, 1979.Google Scholar
  45. 45.
    Naji, A., Silvers, W. K., Bellgraw, D., and Barker, C. F.: Science 213:1390, 1981.PubMedGoogle Scholar
  46. 46.
    Rabinovitch, A., Fuller, L., Mintz, D., Severyn, W., Noel, J., Flaa, C., Kyuriakides, G., and Miller, J.: Clin. Invest. 67:1507, 1981.Google Scholar
  47. 47.
    Lendrum, R., Walker, G., Cudworth, A. G., Theophanides, C., Pyke, D. A., Bloom, A., and Gamble, D. R.: Lancet, 2:\213, 1976.Google Scholar
  48. 48.
    Irvine, W. J., McCallum, C. J., Gray, R. S., Campbell, G. J., Duncan, L. J. P., Farquhar, J. W., Vaughan, J., and Morris, P. J.: Diabetes 26:138, 1977.PubMedGoogle Scholar
  49. 49.
    Bottazzo, G. F., Cudworth, A. G., Moul, D. J., Doniach, D., and Festenstein, H.: Br. Med. J. 2:1253, 1978.PubMedGoogle Scholar
  50. 50.
    Delespesse, G., Gausset, P. H., Sarfati, M., Dubi-Rucquoy, M., Debisschop, M.-J., and van Haelst, L.: Clin. Exp. Immunol 40:96, 1980.PubMedGoogle Scholar
  51. 51.
    Rodger, B., Wittingham, S., Martin, F. I. R., Hawkins, B. R., Hawkins, R. L., and Welbom, T. A.: Clin. Exp. Immunol 89:125, 1980.Google Scholar
  52. 52.
    Doniach, D., Bottazzo, G. F., and Cudworth, A. G.: Annu. Rev. Med 34:13, 1983.PubMedGoogle Scholar
  53. 53.
    Theophanides, C. G., Pyke, D. A., and Watkins, P. J.: Diabetes 27(Suppl.):265, 1978.PubMedGoogle Scholar
  54. 54.
    Rubenstein, A. J., Gonen, B., Irvine, W. J., Taft, A. D., Lemmark, A., Freedman, Z., and Steiner, D. R.: In: Immunology of Diabetes. Edited by W. J. Irvine. Teviot Scientific Publications, Edinburgh, 1980, p. 267.Google Scholar
  55. 55.
    Madsbad, S., Bottazzo, G. F., Cudworth, A. G., Dean, B., Faber, O. K., and Binder, C.: Diabetologia 18:45, 1980.PubMedGoogle Scholar
  56. 56.
    Bottazzo, G. F., and Doniach, D.: Lancet 2:800, 1976.PubMedGoogle Scholar
  57. 57.
    Irvine, W. J.: Lancet 1:638, 1977.PubMedGoogle Scholar
  58. 58.
    Gorsuch, A. N., Spencer, K. M., Lister, J., McNally, J. M., Dean, B. M., Bottazzo, G. F., and Cudworth, A. G.: Lancet 2:1363, 1981.PubMedGoogle Scholar
  59. 59.
    Srikanta, S., Ganda, O. P., Eisenbarth, G. S., and Soeldner, J. S.: N. Engl J. Med 308:322,1983.PubMedGoogle Scholar
  60. 60.
    Sai, P., Boitard, C., Debray-Sachs, M., Pouplard, A., Assan, R., and Hamburger, J.: Diabetes 30:1051, 1981.PubMedGoogle Scholar
  61. 61.
    Rittenhouse, H. G., Oxender, D. L., Pek, S., and Ar, D.: Diabetes 29:311, 1980.Google Scholar
  62. 62.
    Lemmark, A., Kanatsuna, T., Patzelt, C., Diakoumis, K., Carroll, R., Rubenstein, A. H., and Steiner, D. F.: Diabetologia 19:445, 1980.Google Scholar
  63. 63.
    van de Winkel, M., Smets, G., Gepts, W., and Pipeleers, D.: J. Clin. Invest. 70:41, 1982.Google Scholar
  64. 64.
    Bottazzo, G. F., and Doniach, D.: In: Menarini Series on Immunopathology, Vol. 1. Edited by P.-A. Miescher. Schwabe, Basel, 1978, p. 50.Google Scholar
  65. 65.
    Leramark, A., Freedman, Z. R., Hoffman, C., Rubenstein, A. H., Steiner, D. F., Jackson, R. L., Winter, R. J., and Traisman, H. S.: N. Engl. J. Med. 299:375, 1978.Google Scholar
  66. 66.
    Dobersen, M. J., Scharff, J. E., Ginsberg-Fellner, G., and Notkins, A. L.: N. Engl. J. Med. 303:1493, 1980.PubMedGoogle Scholar
  67. 67.
    Marner, B., Lemmark, A., Nerup, J., Molenaar, J. L., Tuk, C. W., and Bivining, G. J.: Diabetologia 25:93, 1983.PubMedGoogle Scholar
  68. 68.
    Bottazzo, G. F., Dean, B. M., Gorsuch, A. N., Cudworth, A. G., and Doniach, D.: Lancet 1:668, 1980.PubMedGoogle Scholar
  69. 69.
    Soderstrum, W. K., Freedman, Z. R., and Lernmark, A.: Diabetes 28(Suppl.):397, 1979.Google Scholar
  70. 70.
    Nerup, J., Anderson, O. O., Bendixen, G., Egeberg, J., and Poulsen, J. E.: Diabetes 20:424, 1971.PubMedGoogle Scholar
  71. 71.
    MacCuish, A. C., Jordan, J., Campbell, C. J., Duncan, L. J. P., and Irvine, W. J.: Diabetes 23:693, 1974.PubMedGoogle Scholar
  72. 72.
    MacCuish, A. C., Urbaniak, S. J., Campbell, C. J., Duncan, L. J. P., and Irvine, W. J.: Diabetes 23:708, 1974.PubMedGoogle Scholar
  73. 73.
    Hann, S., Kay, R., and Falkner, B.: Diabetes 25:101, 1976.PubMedGoogle Scholar
  74. 74.
    Stratton, J. A., Nies, K. M., Lovie, S., and Sperling, M. A.: Diabetes 26(SuppL):419, 1977.Google Scholar
  75. 75.
    Müller, R., Kolb, H., Kuschak, D., Jorgens, V., and Gries, F. A.: Clin. Exp. Immunol 39:130, 1980.PubMedGoogle Scholar
  76. 76.
    Roth, M. D., Barg, M., Michalski, R., and Arquilla, E. R.: Diabetes 29:825, 1980.PubMedGoogle Scholar
  77. 77.
    Sachs, J. A., Cudworth, A. G., Jaraquemada, D., Gorsuch, A. N., and Festenstein, H.: Diabetologia 18:41, 1980.PubMedGoogle Scholar
  78. 78.
    Bottazzo, G. F., and Doniach, D.: Lancet 2:800, 1976.PubMedGoogle Scholar
  79. 79.
    Miller, L. V., Stokes, J. D., and Silpipat, C.: Diabetes Care 1:73, 1978.PubMedGoogle Scholar
  80. 80.
    Like, A. A., and Rossini, A. A.: Science 193:415, 1976.PubMedGoogle Scholar
  81. 81.
    Irvine, W. J., Clark, B. F., Scarth, L., Cullen, D. R., Duncan, L. J. P.: Lancet 2:163, 1970.PubMedGoogle Scholar
  82. 82.
    Serjeantson, S., Theophilus, J., Zimmet, P., Corut, J., Crossley, J. R., and Elliot, R. B.: Diabetes 30:26, 1981.PubMedGoogle Scholar
  83. 83.
    Irvine, W. J., DiMario, U., Guy, K., Feek, C. M., Gray, R. S., and Duncan, L. J. P.: J. Clin. Lab. Immunol 1:183, 1978.PubMedGoogle Scholar
  84. 84.
    Huang, S.-W., Haedt, L. H., Rich, S., and Barbosa, J.: Diabetes 30:873, 1981.PubMedGoogle Scholar
  85. 85.
    Lemmark, A., Haglof, B., Freedman, Z. R., Irvine, W. J., Ludvigsson, J., and Holmgren, G.: Diabetologia 20:471, 1981.Google Scholar
  86. 86.
    Horita, M., Suzuki, H., Onodera, T., Ginsberg-Fellner, F., Fauci, A. S., and Notkins, A. L.: J. Immunol 129:1426, 1982.PubMedGoogle Scholar
  87. 87.
    Rossini, A. A., Mordes, J. P., Pelletier, A. M., and Like, A. A.: Science 219:975, 1983.PubMedGoogle Scholar
  88. 88.
    Naji, A., Silvers, W. K., Kimura, H., Bellgraw, D., Markman, J. F., and Barker, C. F.: J. Immunol 130:2168, 1983.PubMedGoogle Scholar
  89. 89.
    Koevary, S., Williams, R. M., Stoller, W., and Chick, W.: Diabetes 32(Suppl. 1):50A, 1983.Google Scholar
  90. 90.
    Gupta, S., Fikrig, S. M., Smiti, K., and Orti, E.: Immunol Lett. 4:289, 1982.PubMedGoogle Scholar
  91. 91.
    Buschard, K., Madsbad, S., and Rygaard, J.: Clin. Exp. Immunol 41:25, 1980.PubMedGoogle Scholar
  92. 92.
    MacCuish, A. C., Jordan, J., Campbell, C. J., Duncan, L. J. P., and Irvine, W. J.: Lancet 2:1529, 1974.PubMedGoogle Scholar
  93. 93.
    Dobersen, M. J., Bell, A. M., Jenson, A. B., Notkins, A. L., and Ginsberg-Fellner, F.: Lancet 2:1078, 1979.PubMedGoogle Scholar
  94. 94.
    Nishiyama, R. H., Torretti, B., Martin, D. B., Pek, S. B., and Keren, D. F.: Lab. Invest. 43:191, 1980.PubMedGoogle Scholar
  95. 95.
    van de Winkel, M., Smets, G., Gepts, W., and Pipeleers, D. G.: Diabetologia 21:338, 1981.Google Scholar
  96. 96.
    Huen, A. H.-J., Haneda, M., Freedman, Z. R., and Lemmark, A.: Diabetes 30(Suppl.):65A, 1981.Google Scholar
  97. 97.
    Huen, A. H.-J., Haneda, M., Freedman, Z. R., Lemmark, A., and Rubenstein, A. H.: Diabetes 32:460, 1983.PubMedGoogle Scholar
  98. 98.
    Dyrberg, T., Nakhooda, A. F., Baekkeskov, S., Poussier, P., Marliss, E. B., and Lemmark, A.: Diabetes 31(Suppl.):19A, 1982.Google Scholar
  99. 99.
    Baekkeskov, S., Dyrberg, T., and Lemmark, A.: Diabetologia 25:138, 1983.Google Scholar
  100. 100.
    Baekkeskov, S., Lernmark, A., and Ludvigsson, J.: Diabetologia 21:245, 1981.Google Scholar
  101. 101.
    Charles, M. A., Suzuki, M., Waldeck, N., Dodson, L. E., Slater, L., Ong, K., Kershnar, A., Buckingham, B., and Golden, M.: Immunol 130:1189, 1983.Google Scholar
  102. 102.
    Kende, M., Dobersen, M. J., Ginsberg-Fellner, F., and Notkins, A. L.: Diabetes 30(Suppl.):65A, 1981.Google Scholar
  103. 103.
    Eisenbarth, G. S., Morris, M. A., and Scearce, R. M.: J. Clin. Invest. 67:403, 1981.PubMedGoogle Scholar
  104. 104.
    Leiter, E. H., Simon, D., Cherry, M., and Phillips, C. A.: Diabetes 30:30, 1981.PubMedGoogle Scholar
  105. 105.
    King, D. W., Fenoglio, C. M., and Lefkowitch, J. H.: General Pathology: Principles and Dynamics. Lea & Febiger, Philadelphia, 1983.Google Scholar

Copyright information

© Plenum Publishing Corporation 1985

Authors and Affiliations

  • Edward R. Arquilla
    • 1
  • David P. Stenger
    • 1
  1. 1.Department of PathologyUniversity of California Irvine Medical CenterOrangeUSA

Personalised recommendations