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Experimental Insulitis

  • Günter Klöppel

Abstract

Three morphological lesions of the pancreas in type I diabetes strongly influence our current understanding of the pathogenesis of this disease. 1–4 First, the majority of patients under 10 years of age dying of acute diabetes exhibit insulitis. Second, though the diabetes in these cases may only have lasted for a few days, the B-cell mass already appears to be reduced to about 80%, without massive B-cell necrosis being present.4 Third, in long-standing type I diabetes, B cells are absent (or almost absent) from the pancreas.3,4 These findings together with other established features, such as the close association of type I diabetes with the HLA specificities DR3/DR4, the occurrence of autoantibodies to islet cells, and the considerable seasonal trend in the onset of the disease suggest that the gradual B-cell loss in type I diabetes is due to an autoimmune process mediated by hereditary as well as environmental factors.

Keywords

Insulin Antibody Venezuelan Equine Encephalitis Virus Venezuelan Equine Encephalitis Single Islet Islet Structure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Publishing Corporation 1985

Authors and Affiliations

  • Günter Klöppel
    • 1
  1. 1.Institute of PathologyUniversity of HamburgHamburgWest Germany

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