Viral Diabetes

  • John E. Craighead


A viral etiology for diabetes mellitus was first proposed over 50 years ago when Gunderson documented an association between community outbreaks of mumps and the occurrence of new cases of abrupt-onset disease.1 Since that time, reports in the literature have emphasized repeatedly the role of mumps virus in the causation of diabetes.2–7 Recently, several additional viruses that commonly infect man have been implicated. Among these, rubella and group B Coxsackieviruses are accorded major attention.8–16 Many features of insulin-dependent, type I diabetes mellitus are consistent with a viral etiology. The disease often is abrupt in onset and some clinicians have noted a preceding episode of virallike illness. Moreover, numerous epidemiological studies document seasonal clustering of new cases, an observation suggesting a relationship to outbreaks of viral infections, in the community.17–21 Studies of sets of identical twins by several groups of investigators also have implicated environmental factors in the pathogenesis of at least some cases of type I diabetes mellitus.22,23


Pancreatic Tissue Blood Glucose Concentration Virus Inoculation Coxsackie Virus Mumps Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Gunderson, E.: J. Infect. Dis., 41:197, 1927.CrossRefGoogle Scholar
  2. 2.
    Harris, H.F.: Boston Med. Surg. J., 140:465, 1899.CrossRefGoogle Scholar
  3. 3.
    Patrick, A.: Br. Med. J., 2:802, 1924.PubMedCrossRefGoogle Scholar
  4. 4.
    Kremer, H.U.: Am. J. Med, 3:257, 1947.PubMedCrossRefGoogle Scholar
  5. 5.
    Hinden, E.: Lancet, 1:1381, 1962.PubMedCrossRefGoogle Scholar
  6. 6.
    Kahana, D., and Berant, M.: Clin. Pediatr. (Philadelphia), 6:124, 1967.CrossRefGoogle Scholar
  7. 7.
    Sultz, H. A., Hart, B. A., Zielezny, M., and Schlesinger, E.R.: J. Pediatr., 86:654, 1975.PubMedCrossRefGoogle Scholar
  8. 8.
    Plotkin, S.A., and Kaye, R.: Pediatrics, 46:650, 1970.PubMedGoogle Scholar
  9. 9.
    Johnson, G. M., and Tudor, R.B.: Am. J. Dis. Child, 120:453, 1970.PubMedGoogle Scholar
  10. 10.
    Forrest, J. M., Menser, M. A., and Burgess, J. A.: Lancet, 2:332, 1971.PubMedCrossRefGoogle Scholar
  11. 11.
    Menser, M. A., Forrest, J. M., Brandsy, R. D., and Hudson, J. R.: In: International Congress Series No. 597. Excerpta Medica, Amsterdam, 1982.Google Scholar
  12. 12.
    Gamble, D. R., Kinsley, M. L., Fitzgerald, M. G., Bolton, R., and Taylor, K.W.: Br. Med. J., 3:627, 1969.PubMedCrossRefGoogle Scholar
  13. 13.
    Yoon, J. W., Austin, M., Onodera, T., and Notkins, A.L.: N. Engl. J. Med, 300:1173, 1979.PubMedCrossRefGoogle Scholar
  14. 14.
    Wilson, C, Conny, J. H., and Thompson, D.: Br. Med J., 2:1008, 1977.CrossRefGoogle Scholar
  15. 15.
    Gladish, R., Hofmann, W., and Waldherr, R.: Z Kardial., 65:537, 1976.Google Scholar
  16. 16.
    Tauri, S., Toyoshima, H., Namba, M., and Nonaka, K. M.: In:International Congress Series No. 597. Excerpta Medica, Amsterdam, 1982.Google Scholar
  17. 17.
    John, H.S.: J. Pediatr., 35:723, 1949.PubMedCrossRefGoogle Scholar
  18. 18.
    Adams, S.F.: Arch. Intern Med, 37:861, 1926.CrossRefGoogle Scholar
  19. 19.
    Danowski, T. S.: Diabetes Mellitus with Emphasis on Children and Young Adults. Williams & Wilkins, Baltimore, 1957, p. 129.Google Scholar
  20. 20.
    Gamble, D. R.: Postgrad Med J., 50(Suppl. 3):538, 1974.PubMedGoogle Scholar
  21. 21.
    Gleason, R., Kahn, C. B., Funk, I., and Craighead, J.E.: Int. J. Epidemiol, 11:39, 1982.PubMedCrossRefGoogle Scholar
  22. 22.
    Tattersall, R. B., and Fyke, D. A.: Lancet, 2:1120, 1972.PubMedCrossRefGoogle Scholar
  23. 23.
    Gottlieb, M. S., and Root, H. F.: Diabetes, 17:693, 1968.PubMedGoogle Scholar
  24. 24.
    Nerup, J., Platz, P., Nielson, L. S., Anderson, O. O., Christy, M., Lyngsoe, J., Thomsen, M., Poulsen, J. E., Ryder, L. P., and Svejgaard, A.: Lancet 2:864, 1974.PubMedCrossRefGoogle Scholar
  25. 25.
    Platz, P., Jakobsen, B. K., Morling, N., Ryder, L. P., Svejgaard, A., Thomsen, M., Christy, M., Kromann, H., Benn, J., Nerup, J., Green, A., and Hauge, M.: Diabetologia, 21:108, 1981.PubMedCrossRefGoogle Scholar
  26. 26.
    Barbosa, J., Noreen, H., and Yunis, E.J.: N. Engl J. Med., 298:462, 1978.PubMedCrossRefGoogle Scholar
  27. 27.
    Craighead, J. E., and Steinke, J.: Am. J. Pathol., 63:119, 1971.PubMedGoogle Scholar
  28. 28.
    Hayashi, K., Boucher, D. W., and Notkins, A.L.: Am. J. Pathol, 75:91, 1974.PubMedGoogle Scholar
  29. 29.
    Wellmann, K. F., Amsterdam, D., Brancato, P., and Volk, B. W.:Diabetologia, 8:349, 1972.CrossRefGoogle Scholar
  30. 30.
    Müntefering, H., Schmidt, W. A. K., and Korber, W.: Dtsch. Med. Wochenschr., 96:693, 1971.PubMedCrossRefGoogle Scholar
  31. Andrews, C., and Pereira, H. G.: Viruses of Vertebrates. Ballière, Tindall & Cassell, London, 1967.Google Scholar
  32. 32.
    Kissling, R.E., Vanella, J. M., and SchaefFer, M.: Proc. Soc. Exp. Biol Med, 91:148, 1956.PubMedGoogle Scholar
  33. 33.
    Warren, J., Russ, S. B., and Jeffries, H.: Proc. Soc. Exp. Biol Med, 71:376, 1949.PubMedGoogle Scholar
  34. 34.
    Gainer, J. H., and Murchison, T.E.: Vet. Med, 56:173, 1961.Google Scholar
  35. 35.
    Craighead, J. E., Peralta, P. H., and Shelokov, A.: Proc. Soc. Exp. Biol Med, 114:500, 1963.PubMedGoogle Scholar
  36. 36.
    Zonkers, A.H.: Am. J. Trop. Med Hyg., 10:593, 1961.Google Scholar
  37. 37.
    Craighead, J.E.: Am. J. Pathol, 48:333, 1966.PubMedGoogle Scholar
  38. 38.
    Craighead, J.E.: Am. J. Pathol, 48:375, 1966.PubMedGoogle Scholar
  39. 39.
    Pappenheimer, A. M., Kunz, L. J., and Richardson, S.: J. Exp. Med, 94:45, 1951.PubMedCrossRefGoogle Scholar
  40. 40.
    Godman, G. C., Bunting, H., and Melnick, J.L.: Am. J. Pathol, 28:223, 1952.PubMedGoogle Scholar
  41. 41.
    Piatt, H.: Virology, 9:484, 1959.CrossRefGoogle Scholar
  42. 42.
    Piatt, H.: J. Pathol Bacteriol, 75:119, 1958.Google Scholar
  43. 43.
    Mumane, T. G., Craighead, J. E., Mondragon, H., and Shelokov, A.: Science, 131:498, 1960.CrossRefGoogle Scholar
  44. 44.
    Craighead, J. E., Kanich, R. E., and Kessler, J.B.: Am. J. Pathol, 74:287, 1974.PubMedGoogle Scholar
  45. 45.
    Boucher, D. W., and Notkins, A.L.: J. Exp. Med, 137:1226, 1973.PubMedCrossRefGoogle Scholar
  46. 46.
    Wilson, G. L., D’Andrea, B. J., Bellomo, S. C., and Craighead, J. E.: Nature (London), 285:112, 1980.CrossRefGoogle Scholar
  47. 47.
    Yoon, J.-W., McClintock, P. R., Onodera, T., and Notkins, A.L.: J. Exp. Med, 152:878, 1980.PubMedCrossRefGoogle Scholar
  48. 48.
    Iwo, K., Bellomo, S. C., Mukai, N., and Craighead, J. E.: Diabetologia, 25:39, 1983.PubMedCrossRefGoogle Scholar
  49. 49.
    Stefan, Y., Malaisse-Lagae, F., Yoon, J.-W., Notkins, A.L., and Orci, L.: Diabetologia, 15:395, 1978.PubMedCrossRefGoogle Scholar
  50. 50.
    Boucher, D. W., Hayashi, K., Rosenthal, J., and Notkins, A.L.: J. Infect. Dis., 131:462, 1975.PubMedCrossRefGoogle Scholar
  51. 51.
    Morrow, P., Freedman, A., and Craighead, J. E.: Diabetologia, 18:247, 1980.PubMedCrossRefGoogle Scholar
  52. Debons, A. F., Krimsky, I., Likuski, H. J., From, A., and Cloutier, R. J.: Am. J. Physiol, 214:652, 1968.PubMedGoogle Scholar
  53. 53.
    Craighead, J. E.: In: Immunity and Autoimmunity in Diabetes Mellitus: Proceedings of the Francqui Foundation Colloquia. Edited by P. A. Bastenie. Elsevier, Excerpta Medica, Amsterdam, 1974, p. 227.Google Scholar
  54. 54.
    Ross, M. E., Onodera, T., Brown, K. S., and Notkins, A. L.: Diabetes, 25:190, 1976.PubMedCrossRefGoogle Scholar
  55. 55.
    Craighead, J. E., and Higgins, D.: J. Exp. Med., 139:414, 1974.PubMedCrossRefGoogle Scholar
  56. 56.
    Kromann, I., Vestergaard, B.F., and Nerup, J.: Acta Endocrinol (Copenhagen), 76:670, 1974.Google Scholar
  57. 57.
    Yoon, J. W., and Notkins, A.L.: J. Exp. Med., 143: 1170, 1976.PubMedCrossRefGoogle Scholar
  58. 58.
    D’Andrea, B. J., Wilson, G. L., and Craighead, J. E.: Diabetes, 30:451, 1981.PubMedCrossRefGoogle Scholar
  59. 59.
    Chick, W. L., and Like, A.A.: Am. J. Physiol, 221:202, 1971.PubMedGoogle Scholar
  60. 60.
    Dafoe, D. C., Naji, A., Plotkin, S. A., and Barker, C. F.: Surg Res., 28:338, 1980.CrossRefGoogle Scholar
  61. 61.
    Wilson, G. L., Bellomo, S. C., and Craighead, J. E.: Diabetologia, 24:38, 1982.Google Scholar
  62. 62.
    Craighead, J.E.: N. Engl J. Med, 299:1439, 1978.PubMedCrossRefGoogle Scholar
  63. 63.
    Cudworth, A. G.: Diabetologia, 14:281, 1978.PubMedCrossRefGoogle Scholar
  64. 64.
    Meyenburg, H.: Schweiz. Med. Wochenschr., 70:554, 1940.Google Scholar
  65. 65.
    Gepts, W.: Diabetes, 14:619, 1965.PubMedGoogle Scholar
  66. 66.
    Basteni, P. A.: In: International Congress Series No. 312. Excerpta Medica, Amsterdam, 1974.Google Scholar
  67. 67.
    Jansen, F. K., Müntefering, H., and Schmidt, W.A.K.: Diabetologia, 13:549, 1977.CrossRefGoogle Scholar
  68. 68.
    Buschard, K., Rygaard, J., and Lund, E.: Acta Pathol Microbiol Scand. Sect. C., 84:299, 1976.Google Scholar
  69. 69.
    Buschard, K., Hastrup, N., and Rygaard, J.: Diabetologia, 24:42, 1983.PubMedCrossRefGoogle Scholar
  70. 70.
    Dafoe, D. C., Naji, A., and Barker, C. F.: Diabetes, 29:529, 1980.Google Scholar
  71. Huber, S. A., and Craighead, J. E.: Unpublished data.Google Scholar
  72. Lemmark, A.: Personal communication.Google Scholar
  73. 73.
    Kibrick, S., and Benirschke, K.: N. Engl J. Med., 255:883, 1956.PubMedCrossRefGoogle Scholar
  74. 74.
    Sussman, M. L., Strauss, L., and Hodes, H.L.: Am. J. Dis. Child., 97:183, 1959.Google Scholar
  75. 75.
    Craighead, J. E.: In: Handbook of Physiology, Sect. 7, Vol. 1. Edited by R. O. Greep, E. B. Astwood, D. F. Steiner, N. Freinkel, and S. R. Geiger. Amer. Physiological Society, Washington, D.C, 1972, p. 315.Google Scholar
  76. 76.
    Jenson, A. B., Rosenberg, H. S., and Notkins, A. L.: Lancet, 22:354, 1980.Google Scholar
  77. 77.
    Harrison, A. K., Bauer, S. P., and Murphy, F.A.: Exp. Mol. Pathol, 17:206, 1972.PubMedCrossRefGoogle Scholar
  78. 78.
    Burch, G. E., Tsui, C. Y., Harb, J. M., and Colcolough, H.L.: Arch. Intern. Med, 128:40, 1971.PubMedCrossRefGoogle Scholar
  79. 79.
    Webb, S. R., and Madge, G.R.: J. Infect. Dis., 141:47, 1980.PubMedCrossRefGoogle Scholar
  80. 80.
    Cook, S. H. S., Loria, R. M., and Madge, G.E.: Lab. Invest., 46:377, 1982.PubMedGoogle Scholar
  81. 81.
    Coleman, T. J., Taylor, K. W., and Gamble, D. R.: Diabetologia, 10:755, 1983.CrossRefGoogle Scholar
  82. 82.
    Webb, S. R., Loria, R. M., Madge, G. E., and Kibrick, S.: J. Exp. Med, 143:1239, 1976.PubMedCrossRefGoogle Scholar
  83. 83.
    Yoon, J.-W., Onodera, T., and Notkins, A.L: J. Exp. Med, 148:1068, 1978.PubMedCrossRefGoogle Scholar
  84. 84.
    Toniolo, A., Onodera, T., Jordan, G., Yoon, J.-W., and Notkins, A. L.: Diabetes, 31:496, 1982.PubMedCrossRefGoogle Scholar
  85. 85.
    Kund, W. D., Liu, C., and Rodina, P.: J. Immunol, 96:39, 1966.Google Scholar
  86. 86.
    Jährling, P. B., and Scherer, W.F.: Am. J. Pathol, 72:25, 1973.PubMedGoogle Scholar
  87. 87.
    Gorelkin, L., and Jährling, P.B.: Am. J. Pathol, 75:349, 1974.PubMedGoogle Scholar
  88. 88.
    Rodriguez, G.: Patologia (Madrid), 13:297, 1975.Google Scholar
  89. 89.
    Rayfield, E. J., Jährling, P. B., Gorelkin, L., and Cumow, R. T.: Diabetes, 23:345, 1974.Google Scholar
  90. 90.
    Rayfield, E. J., Gorelkin, L., Curnow, R. T., and Jährling, P. B.:Diabetes, 25:623, 1976.PubMedCrossRefGoogle Scholar
  91. Rayfield, E. J., Seto, Y., Goldberg, S. L., Schulman, R. H., and Walker, G.F.: Diabetes, 28:799, 1979.PubMedGoogle Scholar
  92. 92.
    Rayfield, E.J., Seto, Y., Walsh, S., and McEvoy, R.C: J. Clin. Invest., 68:1172, 1981.PubMedCrossRefGoogle Scholar
  93. 93.
    Bowen, G. S., Rayfield, E. J., Monatin, T. R., and Kemp, G.E.: J. Med Virol, 6:227, 1980.PubMedCrossRefGoogle Scholar
  94. 94.
    Smith, M. G., and Vellios, F.: Arch. Pathol, 50:862, 1950.Google Scholar
  95. 95.
    Worth, W. A., and Howard, H.L.: Am. J. Pathol, 26:17, 1950.PubMedGoogle Scholar
  96. 96.
    Wyatt, J. P., Saxton, J., Lee, R. S., and Pinkerton, H.: J. Pediatr., 36:271, 1950.PubMedCrossRefGoogle Scholar
  97. 97.
    Kissane, J. M., and Smith, M. G.: Pathology of Infancy and Childhood. Mosby, St. Louis, 1967, p. 92.Google Scholar
  98. 98.
    Craighead, J.E.: Prog. Med Virol, 19:161, 1975.PubMedGoogle Scholar
  99. 99.
    Hultquist, G., Nordvall, S., and Sundstrom, C: UpsalaJ. Med. Sei., 78:139, 1973.CrossRefGoogle Scholar
  100. 100.
    Gepts, W.: Personal communication.Google Scholar
  101. 101.
    Brody, A. R., and Craighead, J.E.: J. Infect. Dis., 129:677, 1974.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1985

Authors and Affiliations

  • John E. Craighead
    • 1
  1. 1.Department of PathologyUniversity of VermontBurlingtonUSA

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