The Islets of Infants of Diabetic Mothers

  • Bruno W. Volk
  • Klaus F. Wellmann


Ever since Dubreuil and Anderodias1 observed, in 1920, the occurrence of pancreatic islet hypertrophy in a newborn infant and attributed this change to the hyperglycemic state of its diabetic mother, the relationship between a disturbed maternal carbohydrate metabolism and various pathologic alterations in the pancreas and in other tissues of the fetus or neonate has been the subject of a large number of reports in the medical literature. These include review articles concerned with the clinical2–17 and morphologic aspects of this relationship as well as pertinent reports of single1,16–18,31–47 or multiple cases.6,17,19,20,40,48–73 In the present chapter, the literature on quantitative, qualitative, and functional islet cell changes in neonates of diabetic mothers will be reviewed. To be discussed also are findings pertaining to the pancreas as a whole, some experimental data, questions related to the pathogenesis of the described alterations, and the problem of the development of permanent diabetes in infants born to diabetic mothers.


Islet Cell Diabetic Woman Diabetic Mother Maternal Diabetes Islet Tissue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Publishing Corporation 1985

Authors and Affiliations

  • Bruno W. Volk
    • 1
  • Klaus F. Wellmann
    • 2
  1. 1.Department of PathologyUniversity of California Irvine Medical CenterOrangeUSA
  2. 2.Department of PathologyState University of New York, Downstate Medical CenterBrooklynUSA

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