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B-Lymphocyte Development and Heterogeneity

Analysis with the Immune-Defective CBA/N Mouse Strain

  • Chapter
Immunologic Defects in Laboratory Animals 1

Abstract

CBA/N (CN) mice (originally referred to as CBA/HN) are a distinct subline, derived originally from the CBA/Harwell line at the National Institutes of Health (NIH), Bethesda, Maryland. Mice of the Harwell line, which were heterozygous for the lethal foam cell reticulosis gene (fm), were obtained at the NIH in 1966. These mice were bred and normal homozygous progeny were used to reestablish the inbred strain by brothersister matings. However, because of a breeding crisis at the seventh generation, subsequent mice were derived from the litter of a single pregnant female. At the time of the first publication concerning the immune-defective CN mice, 15–25 generations of brother-sister matings had occurred (Amsbaugh et ai, 1972). CN mice reproduce as well as other inbred mouse lines and exist as a vigorous line that has no difficulty in dealing with the routine laboratory environment.

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Authors and Affiliations

  1. Naval Medical Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland, 20014, USA

    Irwin Scher

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  1. Irwin Scher
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Editors and Affiliations

  1. University of California School of Medicine, Davis, California, USA

    M. Eric Gershwin

  2. Food and Drug Administration, Bethesda, Maryland, USA

    Bruce Merchant

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© 1981 Plenum Press, New York

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Scher, I. (1981). B-Lymphocyte Development and Heterogeneity. In: Gershwin, M.E., Merchant, B. (eds) Immunologic Defects in Laboratory Animals 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0325-2_8

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  • DOI: https://doi.org/10.1007/978-1-4757-0325-2_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-0327-6

  • Online ISBN: 978-1-4757-0325-2

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