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B-Lymphocyte Development and Heterogeneity

Analysis with the Immune-Defective CBA/N Mouse Strain
  • Irwin Scher

Abstract

CBA/N (CN) mice (originally referred to as CBA/HN) are a distinct subline, derived originally from the CBA/Harwell line at the National Institutes of Health (NIH), Bethesda, Maryland. Mice of the Harwell line, which were heterozygous for the lethal foam cell reticulosis gene (fm), were obtained at the NIH in 1966. These mice were bred and normal homozygous progeny were used to reestablish the inbred strain by brothersister matings. However, because of a breeding crisis at the seventh generation, subsequent mice were derived from the litter of a single pregnant female. At the time of the first publication concerning the immune-defective CN mice, 15–25 generations of brother-sister matings had occurred (Amsbaugh et ai, 1972). CN mice reproduce as well as other inbred mouse lines and exist as a vigorous line that has no difficulty in dealing with the routine laboratory environment.

Keywords

Normal Mouse Spleen Cell Purify Protein Derivative Immune Defect Normal Adult Mouse 
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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Irwin Scher
    • 1
  1. 1.Naval Medical Research InstituteUniformed Services University of the Health SciencesBethesdaUSA

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