Cyclic Hematopoiesis in Gray Collie Dogs
Cyclic hematopoiesis is a rare human disease for which a spontaneously occurring animal model was recognized in purebred collies in the 1960s. Initially the canine disease was called the “lethal gray syndrome” or the “silver-gray collie syndrome” because the affected collie puppies are born with gray coat color and they die prematurely. Dickson (1964) reported that the puppies die because of an absence of blood neutrophils with consequent infection. Lund et al. (1967) subsequently demonstrated that the dogs have cyclic neutropenia. In 1972, Dale et al. (1972a) reported that the reticulocytes, platelets, monocytes, eosinophils, and lymphocytes also fluctuate periodically and suggested that the name “cyclic hematopoiesis” more accurately describes this disorder.
KeywordsNeutrophil Count Pluripotent Stem Cell Gray Collie Cyclical Change Reticulocyte Count
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