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Cyclic Hematopoiesis in Gray Collie Dogs

  • William P. HammondIV
  • David C. Dale

Abstract

Cyclic hematopoiesis is a rare human disease for which a spontaneously occurring animal model was recognized in purebred collies in the 1960s. Initially the canine disease was called the “lethal gray syndrome” or the “silver-gray collie syndrome” because the affected collie puppies are born with gray coat color and they die prematurely. Dickson (1964) reported that the puppies die because of an absence of blood neutrophils with consequent infection. Lund et al. (1967) subsequently demonstrated that the dogs have cyclic neutropenia. In 1972, Dale et al. (1972a) reported that the reticulocytes, platelets, monocytes, eosinophils, and lymphocytes also fluctuate periodically and suggested that the name “cyclic hematopoiesis” more accurately describes this disorder.

Keywords

Neutrophil Count Pluripotent Stem Cell Gray Collie Cyclical Change Reticulocyte Count 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • William P. HammondIV
    • 1
  • David C. Dale
    • 1
  1. 1.Department of MedicineSchool of Medicine University of WashingtonSeattleUSA

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