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Immunologic Defects in Laboratory Animals 1 pp 309–324Cite as

Immunologic and Hematologic Deficiencies of the Hypopituitary Dwarf Mouse

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Abstract

The immunodeficiency syndrome of the dwarf mouse has provided a model for studying the relationship between the endocrine and the lymphoid systems. Two autosomal recessive dwarf mutants, the Snell-Bagg (SB) dwarf (genetic symbol dw) and the Ames dwarf (genetic symbol df), have been extensively studied. Dwarf mice are indistinguishable from normal siblings during the first week of postnatal life. Thereafter, dwarf mice show reduced body size, juvenile hair growth patterns, and low muscular activity. Both types of dwarf mice exhibit morphologically and physiologically similar characteristics but they derive from entirely different genetic backgrounds.

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Author information

Authors and Affiliations

  1. Blood Center of Southeastern Wisconsin and Department of Microbiology, Medical College of Wisconsin, Milwaukee, Wisconsin, 53201, USA

    Rene J. Duquesnoy & Grete M. Pedersen

Authors
  1. Rene J. Duquesnoy
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  2. Grete M. Pedersen
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Editors and Affiliations

  1. University of California School of Medicine, Davis, California, USA

    M. Eric Gershwin

  2. Food and Drug Administration, Bethesda, Maryland, USA

    Bruce Merchant

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© 1981 Plenum Press, New York

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Duquesnoy, R.J., Pedersen, G.M. (1981). Immunologic and Hematologic Deficiencies of the Hypopituitary Dwarf Mouse. In: Gershwin, M.E., Merchant, B. (eds) Immunologic Defects in Laboratory Animals 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0325-2_14

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  • DOI: https://doi.org/10.1007/978-1-4757-0325-2_14

  • Publisher Name: Springer, Boston, MA

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  • Online ISBN: 978-1-4757-0325-2

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