The Hairless Immune-Deficient Guinea Pig
The guinea pig, or cavy, has been widely used in the fields of microbiology, immunology, and dermatology. Its use in these fields is related to its susceptibility to a wide range of microorganisms by inoculation, to the facility with which it responds to immunogens with antibody and cell-mediated responses, and to the similarity of response of guinea pig skin and human skin for developing contact dermatitis of both the irritant and the allergic types. Renewed appreciation of the guinea pig has occurred as a result of its facility in recovering fastidious organisms such as those responsible for Legionnaire’s disease (McDade et al, 1977) and the Pittsburgh Pneumonia Agent (Myerowitz et ai, 1979; Schwartz, 1979).
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