The Hairless Immune-Deficient Guinea Pig

  • John L. O’Donoghue
  • Carolyn Reed


The guinea pig, or cavy, has been widely used in the fields of microbiology, immunology, and dermatology. Its use in these fields is related to its susceptibility to a wide range of microorganisms by inoculation, to the facility with which it responds to immunogens with antibody and cell-mediated responses, and to the similarity of response of guinea pig skin and human skin for developing contact dermatitis of both the irritant and the allergic types. Renewed appreciation of the guinea pig has occurred as a result of its facility in recovering fastidious organisms such as those responsible for Legionnaire’s disease (McDade et al, 1977) and the Pittsburgh Pneumonia Agent (Myerowitz et ai, 1979; Schwartz, 1979).


Nude Mouse Pharyngeal Pouch Maternal Rejection Gamma Globulin Level Develop Contact Dermatitis 
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  1. Barton, E. C., and Campbell, W. G., 1969, Pneumocystis carinii in the lungs of rats treated with cortisone acetate: Ultrastructural observations relating to the life cycle, Am. J. Pathol. 54: 209.PubMedGoogle Scholar
  2. Berendsen, P. B., and Telford, I. R., 1966, A light and electron microscopic study of Kurloff bodies in the blood and spleen of the guinea pig, Anat. Rec. 156: 107.PubMedCrossRefGoogle Scholar
  3. Berridge, M. V., O’Kech, N., McNeilage, L. J., Heslop, B. F., and Moore, R., 1979, Rat mutant (NZNU) showing “nude” characteristics, Transplantation 27: 410.PubMedGoogle Scholar
  4. Connor, W. S., and Johnson, K. P., 1976, Cytomegalovirus infection in weanling guinea pigs, J. Infect. Dis. 134: 442.PubMedCrossRefGoogle Scholar
  5. Cook, J. E., 1958, Salivary-gland virus disease of guinea pigs, J. Natl. Cancer Inst. 20: 905.PubMedGoogle Scholar
  6. Cooper, G., and Schiller, A. L., 1975, Anatomy of the Guinea Pig, Harvard Univ. Press, Cambridge, Mass.Google Scholar
  7. Davis, G. L., and Hawrisiak, M. M., 1977, Experimental cytomegalovirus infection and the developing mouse ear: In vivo and in vitro studies, Lab. Invest. 37: 20.PubMedGoogle Scholar
  8. Flanagan, S. P., 1966, Nude, a new hairless gene with pleiotropic effects in the mouse, Genet. Res. 8: 295.PubMedCrossRefGoogle Scholar
  9. Goodall, A., 1905, The post-natal changes in the thymus of guinea-pigs, and the effect of castration on thymus structure, J. Physiol. (London) 32: 191.Google Scholar
  10. Gullino, P. M., Ediger, R. D., Giovanella, B., Merchant, B., Outzen, H. C., Reed, N. D., and Wortis, H. H., 1976, Guide for the care and use of the nude (thymus-deficient) mouse in biomedical research, ILAR News 19: M1.Google Scholar
  11. Hashiba, G. K., 1917, The lymphatic system of the guinea pig, Anat. Rec. 12: 331.CrossRefGoogle Scholar
  12. Holub, M., Rossmann, P., Tlaskalova, H., and Vidmarova, H., 1975, Thymus rudiment of the athymic nude mouse, Nature (London) 256: 491.CrossRefGoogle Scholar
  13. Hsu, C. K., Whitney, R. A., Jr., and Hansen, C. T., 1975, Thymus-like lymph node in nude mice, Nature (London) 257: 681.CrossRefGoogle Scholar
  14. Jackson, L., 1920, An intracellular protozoan parasite of the ducts of the salivary glands of the guinea-pig, J. Infect. Dis. 26: 347.CrossRefGoogle Scholar
  15. Klapper, C. E., 1946, The development of the pharynx of the guinea pig with special emphasis on the morphogenesis of the thymus, Am. J. Anat. 78: 139.PubMedCrossRefGoogle Scholar
  16. Landsteiner, K., and Jacobs, J., 1935, Studies on sensitization of animals with simple chemical compounds, J. Exp. Med. 61: 643.PubMedCrossRefGoogle Scholar
  17. Maalouf, H., Gagnon, R., and Bois, P., 1964, Etude descriptive et topographique des ganglions lymphatiques du cobaye, Rev. Can. Biol. 26: 323.Google Scholar
  18. McDade, J. E., Shepard, C. C., Fraser, D. W., Tsai, T. R., Redus, M. R., Dowdley, W. R., and Team, L. E., 1977, Legionnaires’ disease: Isolation of a bacterium and demonstration of its role in other respiratory diseases, N. Engl. J. Med. 297: 1197.PubMedCrossRefGoogle Scholar
  19. Myerowitz, R. L., Pasculle, A. W., Dowling, J. N., Pazin, G. J., Puerzer, M., Yee, R. B., Rinaldo, C. R., and Hakala, T. R., 1979, Opportunistic lung infection due to “Pittsburgh Pneumonia Agent,” N. Engl. f. Med. 301: 953.CrossRefGoogle Scholar
  20. Parks, E. A., 1917, Extirpation of the thymus in the guinea pig, J. Exp. Med. 25: 129.CrossRefGoogle Scholar
  21. Patrizi, G., Middlekamp, J. W., Herweg, J. C., and Thorton, H. K., 1965, Human cytomegalovirus: Electron microscopy of a primary viral isolate, J. Lab. Clin. Med. 65: 825.PubMedGoogle Scholar
  22. Perryman, L. E., Buening, G. M., Mcguire, T. C., Torbeck, R. L., Poppie, M. J., and Sale, G. E., 1979, Fetal tissue transplantation for immunotherapy of combined immunodeficiency in horses, Clin. Immunol. Immunopathol. 12: 238.PubMedCrossRefGoogle Scholar
  23. Reed, C., and O’Donoghue, J. L., 1979, A new guinea pig mutant with abnormal hair production and immunodeficiency, Lab. Animal Sci. 29: 744.Google Scholar
  24. Schwartz, M. N., 1979, Another new pneumonia: Pandora’s box reopened?, N. Engl. J. Med. 301: 995.CrossRefGoogle Scholar
  25. Smith, H. A., Jones, T. C., and Hunt, R. D., 1974, Veterinary Pathology, Lea & Febiger, Philadelphia.Google Scholar
  26. Smith, M. G., 1959, The salivary gland viruses of man and animals (cytomegalic inclusion disease), J. Prog. Med. Virol. 2: 171.Google Scholar
  27. Tegott, D. (ed.), 1973, Beckman Electrophoresis Manual, Beckman Instruments Inc., Fullerton, Calif.Google Scholar
  28. Wortis, H. H., Nehlson, S., and Owen, J. J., 1971, Abnormal development of the thymus in “nude” mice, J. Exp. Med. 134: 681.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • John L. O’Donoghue
    • 1
  • Carolyn Reed
    • 2
  1. 1.Toxicology Section, Health, SafetyHuman Factors Laboratory, Eastman Kodak CompanyRochesterUSA
  2. 2.Department of Laboratory Animal MedicineUniversity of Rochester Medical CenterRochesterUSA

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