Protein Energy Converters
On the basis of experimental evidence, it seems plausible to assume that actin, the main constituent of the thin filaments in muscle, analogously to the coupling factors of mitochondria and chloroplasts, serves as an energy transformer. An approximate stereostructure of actin has been built up on the basis of its known amino acid sequence and the statistical rules of Chou and Fassman. Using analogies to other nucleotide binding proteins, the probable ATP binding site of actin has been pointed out. In the neighborhood of this site, the polypeptide chain is in random coil allowing many different conformations with slightly different energies. Thus this part of the actin molecule could store and release energy via conformational changes. To treat theoretically the conformational changes of a polypeptide chain, a new quantum chemical method for the calculation of the interactions between several molecules is outlined.
KeywordsCoupling Factor Thin Filament Adenyl Kinase Thick Filament Energy Converter
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- (2).L. Margulis in “Origin of eukaryotic cells”, Yale Univ. Press, New Haven and London, (1970).Google Scholar
- (4).A. Oplatka, H. Gadasi, R. Tirosh, Y. Lamed, A. Mühlrad and N. Liron, J. Mechanochem. Cell Motility 2, 295 (1974).Google Scholar
- (6).A. F. Knowles and H. S. Penefsky, J. Biol. Chem. 247, 6617 (1972).Google Scholar
- (7).W. A. Catterall and P. L. Pedersen, J. Biol. Chem. 246, 4987 (1971).Google Scholar
- (16).L. Muszbek, J. A. Gladner and K. Laki, Arch. Biochem. Biophys. (submitted).Google Scholar
- (18).K. Laki, Actin. In “Contractile Proteins and Muscle”, Ed. K. Laki. M. Dekker, New York, 1971, p. 97.Google Scholar
- (23).For a review of the simplified interaction schemes, see R. Rein in “Electronic Structure of Polymers and Molecular Crystals”, ed. J.-M. André and J. Ladik, Plenum Press, London, (1975).Google Scholar
- (26).P. Otto and J. Ladik, Chem. Phys. (sumitted).Google Scholar
- (28).M. Rosenfeld and F. Martino (to be published).Google Scholar
- (29).J. Ladik, F. Martino and M. Rosenfeld (to be published).Google Scholar