Peripheral Dopamine Receptors

  • M. G. Bogaert
  • W. A. Buylaert
  • R. A. Lefebvre
  • J. L. Willems
Part of the New Horizons in Therapeutics book series (NHTH)


In the last 20 years there has been increasing interest in the effects of dopamine both in the CNS and in the periphery. Moreover, much work has been done to elucidate which receptors are involved in these effects.


Dopamine Receptor Presynaptic Receptor Postsynaptic Dopamine Receptor Ganglionic Transmission Central Dopamine Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Abe, K., and Dawes, C, 1982, Dopamine-induced secretion of protein and of some electrolytes by rat submandibular and parotid glands Arch. Oral Biol. 27:635–64.PubMedCrossRefGoogle Scholar
  2. Bastie, M. J., Vaysse, N., Brenac, B., Pascal, J. P., and Ribet, A., 1977, Effects of catecholamines and their inhibitors on the isolated canine pancreas. II. Dopamine, Gastroenterology 72:719–72.PubMedGoogle Scholar
  3. Baumann, H. W., Sturdevant, R. A. L., and McCallum, R. W., 1979, L-Dopa inhibits metoclopramide stimulation of the lower esophageal sphincter in man, Dig. Dis. Sci. 24:289–29.PubMedCrossRefGoogle Scholar
  4. Blancquaert, J. P., Lefebvre, R. A., and Willems, J. L., 1982, Gastric relaxation by intravenous and intracerebroventricular administration of apomorphine, morphine and fentanyl in the conscious dog. Arch. Int. Pharmacodyn 256:153–154.PubMedGoogle Scholar
  5. Bloom, G. D., Carlsöö, B., and Danielsson, Å., 1975, Dopamine-induced amylase secretion from guinea-pig submandibular gland, Br. J. Pharmacol. 54:523–528.PubMedCrossRefGoogle Scholar
  6. Brodde, O.-E., 1982, Vascular dopamine receptors: Demonstration and characterization by in vitro studies. Life Sci. 31:289–306.PubMedCrossRefGoogle Scholar
  7. Brodde, O. E., Meyer, F. J., Schemuth, W., and Freistühler, J., 1981, Demonstration of specific vascular dopamine receptors mediating vasodilatation in the isolated rabbit mesenteric artery, Naunyn Schmiedebergs Arch. Pharmacol. 316:24–30.PubMedCrossRefGoogle Scholar
  8. Brown, D. A., and Caulfield, M. P., 1979, Hyperpolarizing α2-adrenoceptors in rat sympathetic ganglia, Br. J. Pharmacol. 65:435–445.PubMedCrossRefGoogle Scholar
  9. Brown, R. A., and O’Connor, S. E., 1981, Stereoselective antagonism of prejunctional dopamine receptors in the rabbit ear artery by sulpiride, Br. J. Pharmacol. 73:189P–190P.Google Scholar
  10. Buylaert, W. A., Willems, J. L., and Bogaert, M. G., 1977, Vasodilatation produced by apomorphine in the hindleg of the dog, J. Pharmacol. Exp. Ther. 201:738–746.PubMedGoogle Scholar
  11. Buylaert, W. A., Willems, J. L., and Bogaert, M. G., 1978, The receptor mediating the apomorphine vasodilatation in the hindleg of the dog, J. Pharm. Pharmacol. 30:113–115.CrossRefGoogle Scholar
  12. Buylaert, W. A., Willems, J. L., and Bogaert, M. G., 1981, Peripheral prejunctional dopamine receptors, in: Vasodilatation (P. M. Vanhoutte and I. Leusen, eds.), Raven Press, New York, pp. 125–130.Google Scholar
  13. Carlsöö, B., Danielsson, Å., Marklund, S., and Stigbrand, T., 1974, Effects of alpha-and beta-reeeptor blocking agents on catecholamine and 5-hydroxytryptamine induced peroxidase and amylase secretion from guinea pig submandibular gland, Acta Physiol. Scand. 92:263–271.PubMedCrossRefGoogle Scholar
  14. Costall, B., Gunning, S. J., and Naylor, R. J., 1982, Apomorphine contracts and relaxes circular smooth muscle of guinea-pig stomach via action on adrenoceptor mechanisms, Naunyn Schmiedebergs Arch. Pharmacol. 319:226–230.PubMedCrossRefGoogle Scholar
  15. Cox, B., and Ennis, C, 1980, Mechanism of action of dopamine on the guinea-pig gastroesophageal junction in vitro, Br. J. Pharmacol. 71:177–184.PubMedGoogle Scholar
  16. Creese, I., and Sibley, D. R., 1982, Comments on the commentary by Dr. Seeman, Biochem. Pharmacol. 31:2568–2569.CrossRefGoogle Scholar
  17. De Carle, D. J., and Christensen, J., 1976, A dopamine receptor in esophageal smooth muscle of the opossum, Gastroenterology 70:216–219.PubMedGoogle Scholar
  18. Dubocovich, M. L., and Langer, S. Z., 1980, Dopamine and alpha adrenoceptor agonists inhibit neurotransmission in the cat spieen through different presynaptic receptors, J. Pharmacol. Exp. Ther. 212:144–152.PubMedGoogle Scholar
  19. Ennis, C, Janssen, P. A. J., Schnieden, H., and Cox, B., 1979, Characterization of receptors on postganglionic cholinergic neurons in the guinea-pig isolated ileum, J. Pharm. Pharmacol. 31:217–221.PubMedCrossRefGoogle Scholar
  20. Ferrini, R., and Miragoli, G., 1972, Selective antagonism of dopamine by apomorphine, Pharmacol. Res. Commun. 4:347–352.CrossRefGoogle Scholar
  21. Furchgott, R. F., 1972, The classification of adrenoceptors. An evaluation from the standpoint of receptor theory, in: Catecholamines, Handbuch der Experimentellen Pharmakologie, Volume 33 (H. Blaschko and E. Muscholl, eds.), Springer-Verlag Berlin, pp. 283–335.Google Scholar
  22. Furuta, Y., Hashimoto, K., and Washizaki, M., 1978, β-Adrenoceptor Stimulation of exocrine secretion from the rat pancreas, Br. J. Pharmacol. 62:25–29.PubMedCrossRefGoogle Scholar
  23. Glock, D., Kohli, J. D., and Goldberg, L. I., 1982, Domperidone: A potent and highly selective DA2, peripheral dopamine receptor, antagonist, Fed. Proc. 41:1651.Google Scholar
  24. Goldberg, L. I., 1972, Cardiovascular and renal actions of dopamine: Potential clinical applications, Pharmacol. Rev. 24:1–29.PubMedGoogle Scholar
  25. Goldberg, L. I., and Kohli, J. D., 1979, Peripheral pre-and post-synaptic dopamine receptors: Are they different from dopamine receptors in the central nervous system? Commun. Psychopharmacol. 3:447–456.PubMedGoogle Scholar
  26. Goldberg, L. I., and Kohli, J. D., 1981, Agonists and antagonists of peripheral pre-and post-synaptic dopamine receptors: Clinical implications, in: Apomorphine and other dopaminomimetics: Basic Pharmacology, Volume 1 (G. L. Gessa and G. U. Corsini, eds.), Raven Press, New York, pp. 273–284.Google Scholar
  27. Goldberg, L. I., Volkman, P. H., and Kohli, J. D., 1978, A comparison of the vascular dopamine receptor with other dopamine receptors, Annu. Rev. Pharmacol. Toxicol. 18:57–79.PubMedCrossRefGoogle Scholar
  28. Görich, R., Weihrauch, T. R., and Kilbinger, H., 1982, The inhibition by dopamine of cholinergic transmission in the isolated guinea-pig ileum, Naunyn Schmiedebergs Arch. Pharmacol. 318:308–312.PubMedCrossRefGoogle Scholar
  29. Hahn, R. A., Wardell, J. R., Sarau, H. M., and Ridley, P. T., 1982, Characterization of the peripheral and central effects of SK&F 82526, a novel dopamine receptor agonist, J. Pharmacol. Exp. Ther. 223:305–313.PubMedGoogle Scholar
  30. Hashimoto, K., Satho, S., and Takeuchi, O., 1971, Effect of dopamine on pancreatic secretion in the dog, Br. J. Pharmacol. 43:739–746.PubMedCrossRefGoogle Scholar
  31. Horn, P. T., Kohli, J. D., and Goldberg, L. I., 1982a, Facilitation of ganglionic transmission by sulpiride: Evidence for an inhibitory role of dopamine in the canine sympathetic ganglion, J. Pharmacol. Exp. Ther. 223:462–468.Google Scholar
  32. Horn, P. T., Kohli, J. D., and Goldberg, L. I., 1982b, Effects of dopamine, N-N-di-n-propyl dopamine, and (R)-and (S)-sulpiride on guinea pig blood pressure, J. Cardiovasc. Pharmacol. 4:668–675.CrossRefGoogle Scholar
  33. Hovendal, C. P., Bech, K., Gottrup, F., and Andersen, D., 1982, Effect of dopamine on pentagastrin-stimulated gastric acid secretion and mucosal blood flow in dogs with gastric fistula, Scand. J. Gastroenterol. 17:97–102.PubMedCrossRefGoogle Scholar
  34. Imbs, J. L., Schmidt, M., Ehrhardt, J. D., and Schwartz, J., 1979, Renal dopaminergic mechanisms, in: Advances in the Biosciences: Peripheral Dopaminergic Receptors, Volume 20 (J. L. Imbs and J. Schwartz, eds.), Pergamon Press, Oxford, New York, pp. 331–343.Google Scholar
  35. Kebabian, J. W., and Calne, D. B., 1979, Multiple receptors for dopamine, Nature 277:93–96.PubMedCrossRefGoogle Scholar
  36. Kohli, J. D., Goldberg, L. I., and McDermed, J. D., 1982, Modification of cardiovascular actions of 2-amino-5,6-dihydroxytetralin by N,N-di-n-propyl substitution, Eur. J. Pharmacol. 81:293–299.PubMedCrossRefGoogle Scholar
  37. Lanfranchi, G. A., Marzio, L., Cortini, C, and Osset, E. M., 1978a, Motor effect of dopamine on human sigmoid colon. Evidence for specific receptors, Am. J. Dig. Dis. 23:257–263.CrossRefGoogle Scholar
  38. Lanfranchi, G. A., Marzio, L., Cortini, C, Trento, L., and Labó, G., 1978b, Effect of dopamine on gastric motility in man: Evidence for specific receptors, in: Gastrointestinal Motility in Health and Disease, Proceedings of the 6th International Symposium on Gastrointestinal Motility (H. L. Duthie, ed.), MTP Press, Lancaster, pp. 161–172.Google Scholar
  39. Lang, W. J., and Woodman, O. L., 1982, Comparison of the vasodilator action of dopamine and dopamine agonists in the renal and coronary beds of the dog, Br. J. Pharmacol. 77:23–28.PubMedCrossRefGoogle Scholar
  40. Langeloh, A., and Jurkiewicz, A., 1982, Analysis of the effects of dopamine and noradrenaline in relation to the proposed postsynaptic dopamine receptor in rat vas deferens, Naunyn Schmiedebergs Arch. Pharmacol. 318:202–209.PubMedCrossRefGoogle Scholar
  41. Langer, S. Z., 1980, Presynaptic regulation of the release of catecholamines, Pharmacol. Rev. 32:337–362.PubMedGoogle Scholar
  42. Lankisch, P. G., and Koop, H., 1978, Dopamine-Wirkung auf die basale Pankreas-Sekretion des Menschen, Dtsch. Med. Wochenschr. 103:391–392.PubMedCrossRefGoogle Scholar
  43. Leedham, J. A., and Pennefather, J. N., 1982, Dopamine acts at the same receptors as noradrenaline in the rat isolated vas deferens, Br. J. Pharmacol. 77:293–299.PubMedCrossRefGoogle Scholar
  44. Lefebvre, R. A., Blancquaert, J. P., Willems, J. L., and Bogaert, M. G., 1983, In vitro study of the inhibitory effects of dopamine on the rat gastric fundus, Naunyn Schmiedebergs Arch. Pharmacol. 322:228–236.PubMedCrossRefGoogle Scholar
  45. Libet, B., 1970, Generation of slow inhibitory and excitatory postsynaptic potentials, Fed. Proc. 29:1945–1956.PubMedGoogle Scholar
  46. Lokhandwala, M. F., and Barrett, R. J., 1982, Cardiovascular dopamine receptors: Physiological, pharmacological and therapeutic implications, J. Autonom. Pharmacol. 3:189–215.CrossRefGoogle Scholar
  47. Long, J. P., Heintz, S., Cannon, J. G., and Kim, J., 1975, Inhibition of the sympathetic nervous system by 5,6-dihydroxy-2-dimethylamino tetralin (M-7), apomorphine and dopamine, J. Pharmacol. Exp. Ther. 192:336–342.PubMedGoogle Scholar
  48. McNay, J. L., McDonald, R. H., and Goldberg, L. I., 1965, Direct renal vasodilatation produced by dopamine in the dog, Circ. Res. 16:510–517.PubMedCrossRefGoogle Scholar
  49. Mukhopadhyay, A. K., and Weisbrodt, N., 1977, Effect of dopamine on esophageal motor function, Am. J. Physiol. 232:E19–E24.PubMedGoogle Scholar
  50. Murphy, V. V., Gilbert, J. C, Goldberg, L. I., and Kuo, J. F., 1976, Dopamine-sensitive adenylate cyclase in canine renal artery, J. Pharm. Pharmacol. 28:567–571.CrossRefGoogle Scholar
  51. Nakamura, J., 1978, The effect of neuroleptics on the dopaminergic and cholinergic S y s t e m s in sympathetic ganglia, Kurume Med. J. 25:241–253.CrossRefGoogle Scholar
  52. Pendieton, R. G., Samler, L., Kaiser, C, and Ridley, P. T., 1978, Studies on renal dopamine receptors with a new agonist, Eur. J. Pharmacol. 51:19–28.CrossRefGoogle Scholar
  53. Rattan, S., and Goyal, R. K., 1976, Effect of dopamine on the esophageal smooth muscle in vivo, Gastroenterology 70:377–381.PubMedGoogle Scholar
  54. Relja, M., Lackovic, Z., and Neff, N. H., 1982, Evidence for the presence of dopaminergic receptors in vas deferens, Life Sci. 31:2571–2575.PubMedCrossRefGoogle Scholar
  55. Roby, A., and Orzechowski, R. F., 1979, Selective postsynaptic dopamine receptor Stimulation by SK&F 38393 in canine mesenteric vasculature, Pharmacologist 21:239.Google Scholar
  56. Sahyoun, H. A., Costall, B., and Naylor, R. J., 1982a, On the ability of domperidone to selectively inhibit catecholamine-induced relaxation of circular smooth muscle of guinea-pig stomach, J. Pharm. Pharmacol. 34:27–33.CrossRefGoogle Scholar
  57. Sahyoun, H. A., Costall, B., and Naylor, R. J., 1982b, Catecholamine-induced relaxation and contraction of the lower oesophageal and pyloric sphineters of guinea-pig stomach: Modification by domperidone, J. Pharm. Pharmacol. 34:318–324.CrossRefGoogle Scholar
  58. Satoh, Y., Satoh, H., and Honda, F., 1980, Dopamine receptor blocking activity of Sulpiride in the canine exoerine pancreas, Jpn. J. Pharmacol. 30:689–699.PubMedCrossRefGoogle Scholar
  59. Schmidt, M., Imbs, J. L., and Schwartz, J., 1981, The vascular dopamine receptor: A review, J. Pharmacol. (Paris) 12:355–382.Google Scholar
  60. Schmidt, M., Imbs, J. L., Giesen, E. M., and Schwartz, J., 1982, Vasodilator effects of dopaminomimetics in the perfused rat kidney, Eur. J. Pharmacol. 84:61–70.PubMedCrossRefGoogle Scholar
  61. Schuurkes, J. A. J., and Van Nueten, J. M., 1981, Effects of dopamine and its antagonist domperidone cannot be explained by an effect on α1-adrenergic receptors, Arch. Int. Pharmacodyn. 250:324–327.PubMedGoogle Scholar
  62. Seeman, P., 1980, Brain dopamine receptors, Pharmacol. Rev. 32:229–313.PubMedGoogle Scholar
  63. Seeman, P., 1982, Nomenclature of central and peripheral dopaminergic sites and receptors, Biochem. Pharmacol. 31:2563–2568.PubMedCrossRefGoogle Scholar
  64. Shepperson, N. B., Duval, N., Massingham, R., and Langer, S. Z., 1982, Differential blocking effects of several dopamine receptor antagonists for peripheral pre-and postsynaptic dopamine receptors in the anesthetized dog, J. Pharmacol. Exp. Ther. 221:753–761.PubMedGoogle Scholar
  65. Simon, A., and Van Maanen, E. F., 1976, Dopamine receptors and dopaminergic nerves in the vas deferens of the rat, Arch. Int. Pharmacodyn. 222:4–15.PubMedGoogle Scholar
  66. Steinsland, O. S., and Hieble, J. P., 1979 Activities of structural analogues of dopamine on prejunctional dopaminergic and alpha adrenergic receptors, in: Advances in the Biosciences: Presynaptic receptors, Volume 18 (S. Z. Langer, K. Starke, and M. L. Dubocovich, eds.), Pergamon Press, Oxford, New York, pp. 93–98.Google Scholar
  67. Szabo, S., 1979, Dopamine disorder in duodenal ulceration, Lancet 2:880–882.PubMedCrossRefGoogle Scholar
  68. Tayo, F. M., 1979, Occurrence of excitatory dopaminoceptors in the rat and guinea-pig vas deferens, Clin. Exp. Pharmacol. Physiol. 6:275–279.PubMedCrossRefGoogle Scholar
  69. Valenzuela, J. E., and Grossman, M. I., 1976, Dopamine stimulates pancreatic secretion and inhibits gastric secretion in dogs, Clin. Res. 24:292A.Google Scholar
  70. Valenzuela, J. E., Defilippi, C, Diaz, G., Navia, E., and Merino, Y., 1979, Effect of dopamine on human gastric and pancreatic secretion, Gastroenterology 76:323–326.PubMedGoogle Scholar
  71. Van Nueten, J. M., and Janssen, P. A. J., 1978, Is dopamine an endogenous inhibitor of gastric emptying? in: Gastrointestinal Motility in Health and Disease, Proceedings of the 6th International Symposium on Gastrointestinal Motility (H. L. Duthie, ed.), MTP Press, Lancaster, pp. 173–180.Google Scholar
  72. Van Nueten, J. M., Ennis, C, Helsen, L., Laduron, P. M., and Janssen, P. A. J., 1978, Inhibition of dopamine receptors in the stomach: An explanation of the gastrokinetic properties of domperidone, Life Sci. 23:453–457.PubMedCrossRefGoogle Scholar
  73. Volkman, P. H., and Goldberg, L. I., 1976, Lack of correlation between inhibition of prolactin release and Stimulation of dopaminergic renal vasodilatation, Pharmacologist 18:130.Google Scholar
  74. Weihrauch, T. R., Förster, Ch.F., and Krieglstein, J., 1979, Evaluation of the effect of domperidone on human esophageal and gastroduodenal motility by intraluminal manometry, Postgrad. Med. J. 55(1):7–10.PubMedGoogle Scholar
  75. Willems, J. L., 1973, Dopamine-induced inhibition of synaptic transmission in lumbar paravertebral ganglia of the dog, Naunyn Schmiedebergs Arch. Pharmacol. 279:115–126.PubMedCrossRefGoogle Scholar
  76. Willems, J. L., Buylaert, W. A., and Bogaert, M. G., 1979, Evidence that dopamine receptors mediate the neurogenic vasodilatation by dopaminergic agents, in: Advances in the Biosciences: Peripheral Dopaminergic Receptors, Volume 20 (J. L. Imbs and J. Schwartz, eds.), Pergamon Press, Oxford, New York, pp. 299–307.Google Scholar
  77. Willems, J. L., Bogaert, M. G., and Buylaert, W., 1981, Preliminary observations on the interaction of domperidone with peripheral dopamine receptors, J. Pharmacol. 31:131–133.Google Scholar
  78. Zar, M. A., Ebong, O. O., and Bateman, D. N., 1982, Effect of metoclopramide in guineapig ileum longitudinal muscle: Evidence against dopamine mediation, Gut 23:66–70.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • M. G. Bogaert
    • 1
  • W. A. Buylaert
    • 1
  • R. A. Lefebvre
    • 1
  • J. L. Willems
    • 1
  1. 1.Heymans Institute of PharmacologyUniversity of Gent Medical SchoolGentBelgium

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