The Kidney and Hypertension

  • Arthur C. Guyton
  • R. Davis Manning
  • Thomas E. Lohmeier
  • John E. Hall
Part of the New Horizons in Therapeutics book series (NHTH)


From the earliest studies on kidney disease it was already apparent that the kidneys play a very important role in Controlling arterial pressure. However, the mechanism or mechanisms by which the kidney affects pressure have remained unclear even to the present. All research workers have known of the obvious possibility that renal disease might cause retention of water and salt in the body and that excess volume could drive the circulatory system toward a higher level of activity, thus causing hypertension. Yet, even Bright (1836) in his classical studies on “Bright’s disease” noted vasospastic phenomena associated with renal hypertension, leading to the suggestion that renal hypertension might result from some circulating vasoconstrictor agent.


Arterial Pressure Essential Hypertension Sodium Intake Salt Intake Total Peripheral Resistance 


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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Arthur C. Guyton
    • 1
  • R. Davis Manning
    • 1
  • Thomas E. Lohmeier
    • 1
  • John E. Hall
    • 1
  1. 1.Department of Physiology and BiophysicsUniversity of Mississippi Medical CenterJacksonUSA

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